1. 重组蛋白
  2. CAR-T related Proteins Receptor Proteins Biotinylated Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Immunoglobulin-like Cell Adhesion Molecules
  5. Nectin-4
  6. Nectin-4 蛋白, Human (Biotinylated, HEK293, His-Avi)

Nectin-4 蛋白, Human (Biotinylated, HEK293, His-Avi)

目录号: HY-P72401
产品使用指南

Nectin-4 蛋白 IgV 结构域在细胞粘附中至关重要,参与反同性和反异性相互作用,尤其是与 NECTIN1 的相互作用。虽然它不充当α-疱疹病毒进入受体,但它充当麻疹病毒的受体,使病毒能够进入宿主细胞。这种双重作用强调了 Nectin-4 在细胞粘附中的重要性及其作为麻疹病毒感染受体的特殊作用。Nectin-4 蛋白, Human (Biotinylated, HEK293, His-Avi) 是重组的 Nectin-4 蛋白,由 HEK293 表达,带有 C-Avi, C-6*His 标签。Nectin-4 蛋白, Human (Biotinylated, HEK293, His-Avi) 全长 320 个氨基酸,分子量为 40-50 kDa。

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     可免费申领三个不同产品的试用装。

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描述

The Nectin-4 Protein IgV domain is pivotal in cell adhesion, participating in trans-homophilic and -heterophilic interactions, notably with NECTIN1. While it doesn't serve as an alpha-herpesvirus entry receptor, it functions as a receptor for measles virus, enabling virus entry into host cells. This dual role underscores the importance of Nectin-4 in cell adhesion and its specific role as a measles virus infection receptor. Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Nectin-4 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi) is 320 a.a., with molecular weight of 40-50 kDa.

研究背景

Nectin-4 蛋白 IgV 结构域在细胞粘附中发挥着至关重要的作用,参与反同性和反异性相互作用。具体来说,它与 NECTIN1 形成相互作用,有助于细胞粘附过程。然而,它不能作为α-疱疹病毒进入细胞的受体。在微生物感染的情况下,Nectin-4 IgV 结构域充当麻疹病毒的受体,促进病毒进入宿主细胞。这凸显了 Nectin-4 在细胞粘附中的双重作用及其作为麻疹病毒感染特异性受体的重要性。

种属

Human

表达系统

HEK293

标签

C-Avi;C-6*His

蛋白编号

Q96NY8 (G32-V351)

基因 ID
蛋白结构
N-term
Nectin-4 (G32-V351)
Accession # Q96NY8
6*His-Avi
C-term
同用名
PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR
氨基酸序列

GELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVV

分子量

40-50 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Nectin-4 Protein, Human (Biotinylated, HEK293, His-Avi)
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HY-P72401
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