1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules T Cell CD Proteins Macrophage CD Proteins
  4. PD-1
  5. PD-1 蛋白, Rhesus Macaque (HEK293, Fc)

PD-1 蛋白, Rhesus Macaque (HEK293, Fc)

目录号: HY-P73349
产品使用指南

程序性细胞死亡蛋白 1 (PDCD1) 是一种免疫抑制受体,通过结合配体 CD274/PDCD1L1 和 CD273/PDCD1LG2 传递抑制信号,在诱导和维持自身免疫耐受中发挥关键作用。PDCD1 在抗肿瘤免疫和自身保护免疫中发挥作用,但也被肿瘤利用 PDCD1 介导的抑制途径来减弱抗肿瘤免疫。PD-1 蛋白, Rhesus Macaque (HEK293, Fc) 是重组的 PD-1 蛋白,由 HEK293 表达,带有 C-hFc 标签。PD-1 蛋白, Rhesus Macaque (HEK293, Fc) 全长 167 个氨基酸,分子量约为 ~42.7 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor which delivers inhibitory signals upon binding to ligands CD274/PDCD1L1 and CD273/PDCD1LG2, playing a critical role in induction and maintenance of immune tolerance to self. PDCD1 plays a role in anti-tumor immunity and is involved in safeguarding against autoimmunity, but PDCD1-mediated inhibitory pathway is also exploited by tumors to attenuate anti-tumor immunity. PD-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Rhesus Macaque (HEK293, Fc) is 167 a.a., with molecular weight of ~42.7 kDa.

研究背景

程序性细胞死亡蛋白 1 (PDCD1) 是一种免疫抑制受体,在活化的 T 细胞中表达,通过结合配体 CD274/PDCD1L1 和 CD273/PDCD1LG2 传递抑制信号。PDCD1 参与 T 细胞功能的调控,包括效应CD8+ T 细胞功能的调控,PDCD1 蛋白还能促进 CD4+ T 细胞向 T 调节性细胞分化,在诱导和维持自身免疫耐受中发挥关键作用。PDCD1 在包括黑色素瘤在内的许多类型的肿瘤中表达,并在抗肿瘤免疫中发挥作用。此外,PDCD1 也参与自身保护免疫,然而,它也有助于抑制有效的抗肿瘤和抗微生物免疫,因为肿瘤利用 PDCD1 介导的抑制途径来减弱抗肿瘤免疫,逃避免疫系统的破坏,从而促进肿瘤生存[1][2]

种属

Rhesus Macaque

表达系统

HEK293

标签

C-hFc

蛋白编号

B0LAJ2 (M1-Q167)

基因 ID
蛋白结构
N-term
PD-1 (M1-Q167)
Accession # B0LAJ2
hFc
C-term
同用名
CD279; hPD-1; PDCD1; Programmed cell death 1; SLEB2
分子量

Approximately 42.7 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
PD-1 Protein, Rhesus Macaque (HEK293, Fc)
目录号:
HY-P73349
需求量: