PD-L2 蛋白, Rat (HEK293, Fc)

Programmed cell death 1 ligand 2 (Pdcd1lg2, Pd-l2, B7-DC) is a member of B7 family and a ligand of programmed cell death 1. Pdcd1lg2 negatively regulates activated T cell proliferation, interferon-gamma production and interleukin-10 production in a PDCD1-independent manner, or inhibits T-cell proliferation by blocking cell cycle progression and cytokine production by interacts with PDCD1, and consequently causes cancer growth and suppresses the immune system. PD-L2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived PD-L2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-L2 Protein, Rat (HEK293, Fc) is 219 a.a., with molecular weight of ~64.6 kDa.

程序性细胞死亡 1 配体 2 (Pdcd1lg2, Pd-l2, B7-DC) 是 B7 家族的成员，是程序性细胞死亡 1 的配体。Pdcd1lg2 由 1 个 IgV 和 1 个 IgC 结构域组成，参与共刺激信号，以不依赖于 PDCD1 的方式负调节激活的 T 细胞增殖、干扰素-γ 产生和白细胞介素 10 产生。Pdcd1lg2 与 PDCD1 的相互作用通过阻断细胞周期进程和细胞因子产生来抑制 T 细胞增殖。Pdcd1lg2 与 PD-1 的相互作用增强了 T 细胞的耐受性，诱导对 T 细胞活化/增殖的抑制作用，增加 T 辅助细胞向 Foxp3+ Treg 细胞的转化，并防止癌细胞中 T 细胞的细胞溶解，以及 因此会导致癌症生长并抑制免疫系统。Pdcd1lg2 主要表达于非造血组织、髓系树突状细胞、巨噬细胞等 APC 上，且 Pdcd1lg 活跃在质膜外侧，是肺结核的生物标志物^[1][2][3][4]。

Rat

HEK293

C-hFc

D4AAV6 (M1-R219)

309304  [NCBI]

Approximately 64.6 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.