PDIA6 蛋白, Human (HEK293, His)

PDIA6 protein has molecular chaperone activity, which can inhibit the aggregation of misfolded proteins and contribute to quality control. It negatively regulates the unfolded protein response (UPR) by binding to ERN1 and inhibiting its signaling. PDIA6 Protein, Human (HEK293, His) is the recombinant human-derived PDIA6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDIA6 Protein, Human (HEK293, His) is 421 a.a., with molecular weight of ~52.0 kDa.

PDIA6 蛋白表现出多种功能，作为伴侣抑制错误折叠蛋白的聚集，从而有助于蛋白质量控制。此外，它通过与 ERN1 等 UPR 传感器结合，对未折叠蛋白反应 (UPR) 进行负调节，导致 ERN1 信号传导失活。此外，PDIA6 可以通过 EIF2AK3 UPR 传感器调制 UPR。除了在蛋白质稳态中的作用外，PDIA6 在各种激动剂（如惊厥蛋白、胶原蛋白和凝血酶）诱导的血小板聚集和激活中也发挥着重要作用。这些多方面的功能强调了 PDIA6 在与蛋白质折叠、质量控制和血小板激活相关的细胞过程中的重要性。需要进一步的研究来揭示这些不同功能背后的具体分子机制，从而深入了解 PDIA6 在细胞生理学中更广泛的调节作用。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

Q15084 (L20-L440)

10130  [NCBI]

LYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL

Approximately 52.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.