1. 重组蛋白
  2. Enzymes & Regulators
  3. Hydrolases (EC 3)
  4. PPM1A 蛋白, Mouse (His)

PPM1A 蛋白, Mouse (His)

目录号: HY-P75979
COA 产品使用指南

PPM1A 是一种多功能酶,其酶活性表现出广泛的特异性。它通过使 SMAD2SMAD3 去磷酸化来充当 TGF-β 信号传导的负调节因子,导致它们与 SMAD4 解离、SMAD 的核输出以及 TGF-β 介导的信号传导终止。PPM1A 蛋白, Mouse (His) 是重组的 PPM1A 蛋白,由 E. coli 表达,带有 C-His 标签。PPM1A 蛋白, Mouse (His) 全长 382 个氨基酸,分子量约为 ~44 kDa。

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描述

PPM1A is a multifunctional enzyme whose enzymatic activity exhibits broad specificity. It acts as a negative regulator of TGF-β signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4, nuclear export of SMAD, and termination of TGF-β-mediated signaling. PPM1A Protein, Mouse (His) is the recombinant mouse-derived PPM1A protein, expressed by E. coli , with C-His labeled tag. The total length of PPM1A Protein, Mouse (His) is 382 a.a., with molecular weight of ~44 kDa.

研究背景

蛋白磷酸酶,Mg2+/Mn2+ 依赖性 1A (PPM1A) 是一种具有广泛特异性的酶。它通过使 SMAD2SMAD3 去磷酸化,充当 TGF-β 信号传导的负调节因子,导致它们从 SMAD4 解离并随后进行核输出。这种酶活性最终终止 TGF-β 介导的信号通路。此外,PPM1A 使 PRKAA1 和 PRKAA2 去磷酸化,有助于调节与 AMP 激活蛋白激酶相关的细胞过程。此外,PPM1A 通过去磷酸化和灭活 IKBKB/IKKB,在终止 TNF-α 介导的 NF-κ-B 激活中发挥关键作用。PPM1A 的多种底物特异性强调了其在调节关键信号传导途径中的重要性,强调了其在细胞对 TGF-β 和 TNF-α 信号传导反应中的调节功能(参考:提供的信息)。

生物活性

Measured by its ability to dephosphorylate the peptide substrate, DLDVPIPGRFDRRVS(PO3)VAAE. The specific activity is 450.99 nmol/min/mg, as measured under the described conditions.

种属

Mouse

表达系统

E. coli

标签

C-6*His

蛋白编号

P49443 (M1-W382)

基因 ID

19042  [NCBI]

蛋白结构
N-term
PPM1A (M1-W382)
Accession # P49443
His
C-term
同用名
Protein Phosphatase 1A; Protein Phosphatase 2C Isoform Alpha; PP2C-Alpha; PPPM1A
氨基酸序列

MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLETWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFRGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPSAPKVSAEAVKKEAELDKYLESRVEEIIKKQVEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSASTDDMW

分子量

Approximately 44 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

PPM1A Protein, Mouse (His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PPM1A Protein, Mouse (His)
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