Prokineticin-1/EG-VEGF 蛋白, Human

Prokineticin-1/EG-VEGF protein is a potent regulator of gastrointestinal smooth muscle contraction and affects intestinal motility. Its multifaceted effects extend to capillary endothelial cells, inducing proliferation, migration, and fenestration and are specific to certain cell types. Prokineticin-1/EG-VEGF Protein, Human is the recombinant human-derived Prokineticin-1/EG-VEGF protein, expressed by E. coli , with tag free.

Prokineticin-1/EG-VEGF 蛋白是胃肠道 (GI) 平滑肌收缩的有效调节剂，突出了其在调节肠道蠕动方面的作用。除了对平滑肌的影响外，这种蛋白质对内分泌腺来源的毛细血管内皮细胞也表现出多方面的影响，诱导增殖、迁移和开窗。重要的是，Prokineticin-1/EG-VEGF 对各种其他内皮细胞和非内皮细胞类型几乎没有影响或没有影响，从而表现出特异性。其作用延伸至肠神经嵴细胞，诱导增殖和分化。在神经母细胞瘤进展中，该蛋白直接影响神经母细胞瘤细胞的增殖和迁移，暗示其参与肿瘤动态。此外，Prokineticin-1/EG-VEGF 正向调节 PTGS2 表达和前列腺素合成，表明其在炎症反应中具有潜在作用。Prokineticin-1/EG-VEGF 对胎盘形成以及正常和病理性睾丸血管生成具有影响，作为一种多功能信号分子，在各种生理和病理环境中具有多种细胞效应。

Measured by its binding ability in a functional ELISA. Immobilized Human EG-VEGF at 2 μg/mL can bind Anti-EG-VEGF antibody. The ED₅₀ for this effect is 42.32 ng/mL.

• 
  Measured by its binding ability in a functional ELISA. Immobilized Human EG-VEGF at 2 μg/mL can bind Anti-EG-VEGF antibody. The ED₅₀ for this effect is 42.32 ng/mL.

Human

E. coli

Tag Free

P58294 (A20-F105)

84432  [NCBI]

Full Length of Mature Protein

AVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF

Approximately 12 kDa, based on SDS-PAGE under reducing conditions.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 0.02% Tween20, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.