1. 重组蛋白
  2. Immune Checkpoint Proteins
  3. Inhibitory Checkpoint Molecules
  4. PVRIG
  5. PVRIG 蛋白, Human (HEK293, mFc)

PVRIG 蛋白, Human (HEK293, mFc)

目录号: HY-P71248
产品使用指南

PVRIG 蛋白作为 NECTIN2 的细胞表面受体发挥作用,并且可以作为能够抑制 T 细胞受体介导的信号传导的共抑制受体。与 NECTIN2 相互作用后,PVRIG 抑制 T 细胞增殖,表明其在调节免疫反应中的潜在作用。PVRIG 蛋白, Human (HEK293, mFc) 是重组的 PVRIG 蛋白,由 HEK293 表达,带有 C-mFc 标签。PVRIG 蛋白, Human (HEK293, mFc) 全长 131 个氨基酸,分子量为 45-55 kDa。

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描述

The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, mFc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PVRIG Protein, Human (HEK293, mFc) is 131 a.a., with molecular weight of 45-55 kDa.

研究背景

PVRIG(含 PVR 相关免疫球蛋白结构域)蛋白被确定为 NECTIN2 的细胞表面受体,作为潜在的共抑制受体,抑制 T 细胞受体介导的信号。与 NECTIN2 相互作用后,PVRIG 通过抑制 T 细胞增殖发挥其抑制作用。值得注意的是,PVRIG 与 NECTIN2 的 CD226 进行竞争性结合,这意味着它在与激活受体竞争的免疫反应中发挥调节作用。这种与 CD226 的竞争性相互作用强调了 PVRIG 参与调节 T 细胞激活过程中激活信号和抑制信号之间的微妙平衡。

种属

Human

表达系统

HEK293

标签

C-mFc

蛋白编号

Q6DKI7 (T41-D171)

基因 ID
蛋白结构
N-term
PVRIG (T41-D171)
Accession # Q6DKI7
mFc
C-term
同用名
C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463
氨基酸序列

TPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRAD

分子量

45-55 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

PVRIG Protein, Human (HEK293, mFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PVRIG Protein, Human (HEK293, mFc)
目录号:
HY-P71248
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