1. 重组蛋白
  2. Immune Checkpoint Proteins
  3. Inhibitory Checkpoint Molecules
  4. PVRIG
  5. PVRIG 蛋白, Mouse (HEK293, Fc)

PVRIG 蛋白, Mouse (HEK293, Fc)

目录号: HY-P70961
产品使用指南

PVRIG 蛋白是 nectin 和 nectin 样家族的成员,是一种具有开发潜力的免疫检查点分子。PVRIG 以高亲和力与效应 T 细胞上的抑制性受体 PVRL2 结合,抑制细胞因子的产生和细胞毒活性。PVRIG阻断抗体显著增加NK细胞的细胞毒性。PVRIG 蛋白, Mouse (HEK293, Fc) 是重组的 PVRIG 蛋白,由 HEK293 表达,带有 C-hFc 标签。PVRIG 蛋白, Mouse (HEK293, Fc) 全长 131 个氨基酸,分子量为 48-55 kDa。

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描述

PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Mouse (HEK293, Fc) is 131 a.a., with molecular weight of 48-55 kDa.

研究背景

脊髓灰质炎病毒受体相关免疫球蛋白结构域 (PVRIG) 是 nectin 和 nectin 样家族的成员,是一种具有开发潜力的免疫检查点分子。在人类中,PVRIG 在 T 细胞(主要是 CD8+ T 细胞)和自然杀伤 (NK) 细胞上表达,但在 B 细胞、单核细胞或中性粒细胞上不表达。PVRIG 与单一配体脊髓灰质炎病毒受体相关 2 (PVRL2) 结合,并可能通过其胞内结构域中的 ITIM 样基序对细胞毒性淋巴细胞活性发挥抑制作用。PVRIG 以高亲和力与效应 T 细胞上的抑制性受体 PVRL2 结合,抑制细胞因子的产生和细胞毒活性。PVRIG 缺陷或 PVRIG 阻断可以通过抑制 NK 细胞和 CD8+ T 细胞耗竭来减小肿瘤大小并延长荷瘤小鼠的生存期。PVRIG 阻断增强自然杀伤细胞对 PVRL2hiPVRlo 急性髓系白血病细胞的杀伤作用[1][2][3]

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

A0A1B0GS01 (S35-D165)

基因 ID

102640920  [NCBI]

蛋白结构
N-term
PVRIG (S35-D165)
Accession # A0A1B0GS01
hFc
C-term
同用名
C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463
氨基酸序列

SPEVWVQVQMEATNLSSFSVHCGVLGYSLISLVTVSCEGFVDAGRTKLAVLHPEFGTQQWAPARQAHWETPNSVSVTLTMGQSKARSSLANTTFCCEFVTFPHGSRVACRDLHRSDPGLSAPTPALNLQAD

分子量

48-55 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

PVRIG Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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HY-P70961
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