1. 重组蛋白
  2. Viral Proteins
  3. SARS-CoV-2 Proteins
  4. SARS-CoV-2 Nucleocapsid Proteins
  5. SARS-CoV-2 N Protein (NP)
  6. SARS-CoV-2 Nucleocapsid 蛋白 (Omicron, B.1.1.529, His)

SARS-CoV-2 Nucleocapsid 蛋白 (Omicron, B.1.1.529, His)

目录号: HY-P74443
COA 产品使用指南

Nucleoprotein/NP 蛋白 对于病毒复制和转录至关重要。Nucleoprotein/NP 蛋白 与病毒 RNA 结合,形成基因组复制所需的核糖核蛋白复合物。Nucleoprotein/NP 蛋白 促进 NLRP3 炎症小体激活来诱导过度炎症。SARS-CoV-2 Nucleocapsid 蛋白 (Omicron, B.1.1.529, His) 是重组的 SARS-CoV-2 核衣壳蛋白,由 E. coli 表达,带有 N-His 标签。SARS-CoV-2 Nucleocapsid 蛋白 (Omicron, B.1.1.529, His) 全长 419 个氨基酸,分子量约为 ~46.31 kDa。

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 μg ¥1560 In-stock
50 μg ¥4250 In-stock
100 μg   询价  

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描述

Nucleoprotein/NP Protein is essential for viral replication and transcription. Nucleoprotein/NP Protein binds to viral RNA to form a ribonucleoprotein complex required for genome replication. Nucleoprotein/NP Protein promotes NLRP3 inflammasome activation to induce excessive inflammation. SARS-CoV-2 Nucleocapsid Protein (Omicron, B.1.1.529, His) is the recombinant Virus-derived SARS-CoV-2 Nucleocapsid protein, expressed by E. coli , with N-His labeled tag. The total length of SARS-CoV-2 Nucleocapsid Protein (Omicron, B.1.1.529, His) is 419 a.a., with molecular weight of ~46.31 kDa.

研究背景

Nucleoprotein/NP Protein 对于病毒复制和转录至关重要。Nucleoprotein/NP Protein 与病毒 RNA 结合,形成基因组复制所需的核糖核蛋白复合物,Nucleoprotein/NP Protein诱导强抗体(Ab) 和 T 细胞反应,调节先天免疫和适应性免疫[1][3]
Nucleoprotein/NP Protein 通过分泌到细胞外空间起作用,在那里它与宿主趋化因子竞争以与宿主糖胺聚糖(GAG) 结合[2]
Nucleoprotein/NP Protein 通过促进 NLRP3 炎症小体激活来诱导过度炎症,这在 COVID 肺损伤中发挥作用[4]

种属

Virus

表达系统

E. coli

标签

N-His

蛋白编号

YP_009724397 (M1-A419)

基因 ID

43740575  [NCBI]

蛋白结构
N-term
His
Nucleocapsid (M1-A419)
Accession # YP_009724397
C-term
同用名
N Protein; Nucleocapsid
分子量

Approximately 46.31 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

性状

溶液.

组分

Supplied as a 0.2 μm filtered solution of 50 mM PB, 500mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

N/A.

保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.

文件资料

SARS-CoV-2 Nucleocapsid Protein (Omicron, B.1.1.529, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
SARS-CoV-2 Nucleocapsid Protein (Omicron, B.1.1.529, His)
目录号:
HY-P74443
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