TAFA5/FAM19A5 蛋白, Mouse (His)

As a chemokine-like molecule, TAFA5/FAM19A5 protein activates GPCRs such as S1PR2 and FPR2 to regulate cell proliferation and migration. It induces macrophage chemotactic migration through MAPK3/ERK1 and AKT1 pathways and inhibits TNFSF11/RANKL-induced osteoclast formation. TAFA5/FAM19A5 Protein, Mouse (His) is the recombinant mouse-derived TAFA5/FAM19A5 protein, expressed by E. coli , with N-His labeled tag. The total length of TAFA5/FAM19A5 Protein, Mouse (His) is 89 a.a., with molecular weight of 13-14 kDa.

TAFA5/FAM19A5 作为一种趋化因子样蛋白，通过激活 G 蛋白偶联受体 (GPCR)，尤其是 S1PR2 和 FPR2，协调细胞增殖和迁移。它通过 MAPK3/ERK1 和 AKT1 途径刺激巨噬细胞的趋化性迁移，同时通过阻止破骨细胞融合和分化基因的上调（由 GPCR FPR2 介导的过程）来抑制 TNFSF11/RANKL 诱导的破骨细胞形成。作为脂肪因子，TAFA5/FAM19A5 通过 GPCR S1PR2 和 G 蛋白 GNA12/GNA13 传递的 RHOA 信号传导，响应血小板衍生生长因子的刺激，负向调节血管平滑肌细胞 (VSMC) 增殖和迁移。这种多方面的作用延伸到抑制股动脉中损伤诱导的细胞增殖和新内膜形成，强调了其对多种细胞过程的调节影响。

Mouse

E. coli

N-His

Q91WE9-1 (T44-S132)

/

13-14 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液

Supplied as a 0.22μm filtered solution of 20mM Tris, 300mM NaCl, 10% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.