TRIM72 蛋白, Human (His)

TRIM72 Protein, Human (His) is the recombinant human-derived TRIM72, expressed by E. coli , with His labeled tag. ,

TRIM72 是一种肌肉特异性的 E3 泛素-蛋白连接酶，在细胞膜修复中起核心作用，通过募集修复复合体至损伤部位（PubMed:36944613）。其泛素化活性由 E2 泛素结合酶 UBE2D1、UBE2D2 和 UBE2D3 介导（By similarity）。它作为氧化感应器发挥作用：在膜损伤时，细胞外氧化环境导致二硫键形成并在损伤部位发生同源寡聚化（By similarity）。这种寡聚化作为募集含 TRIM72 囊泡至损伤部位的成核位点，促进膜斑块形成（By similarity）。可能作用于 Ca²⁺ 依赖性膜再密封过程的上游（By similarity）。在修复斑块形成过程中，负责运输 DYSF 至细胞损伤部位（By similarity）。调控膜出芽和胞吐作用（By similarity）。可能参与调节含 KCNB1 内吞囊泡的移动性（By similarity）。

Human

E. coli

N-His

Q6ZMU5-1 (S2-A477)

493829

Partial

Approximately 54.8 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol, 1 mM DTT.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.