2. 重组蛋白
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. Trk Receptors TrkA
  6. TrkA 蛋白, Canine (HEK293, His)

TrkA 蛋白, Canine (HEK293, His)

目录号: HY-P73456
产品使用指南

TrkA 蛋白 (isoform 3) 属于神经生长因子受体家族成员，能促进血管生成，并在过度表达时具有致癌活性。TrkA 蛋白 (isoform 3) 拮抗促进神经元前体分化的抗增殖性 NGF-NTRK1 信号。TrkA 蛋白, Canine (HEK293, His) 是重组的 TrkA 蛋白，由 HEK293 表达，带有 N-His 标签。TrkA 蛋白, Canine (HEK293, His) 全长 126 个氨基酸，分子量为 27-33 kDa。

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描述

TrkA Protein (isoform 3) belongs to the nerve growth factor receptor family and can promote angiogenesis and has carcinogenic activity when overexpressed. TrkA Protein (isoform 3) antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes the differentiation of neuronal precursors. TrkA Protein, Canine (HEK293, His) is the recombinant canine-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Canine (HEK293, His) is 126 a.a., with molecular weight of 27-33 kDa.
研究背景

TrkA Protein (isoform 3) 仅在未分化的早期神经祖细胞、人类神经母细胞瘤 (NBs) 和其他神经嵴源性肿瘤的亚群中表达，能促进血管生成，并在过度表达时具有致癌活性。TrkA Protein (isoform 3) 拮抗促进神经元前体分化的抗增殖性 NGF-NTRK1 信号[1]。
种属

Canine
表达系统

HEK293
标签

N-His
蛋白编号

XP_851619.3 (P285-K410)
基因 ID
蛋白结构
N-term
His
TrkA (P285-K410)
Accession # XP_851619.3
C-term
同用名
High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK
分子量

27-33 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TrkA Protein, Canine (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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