1. 重组蛋白
  2. Receptor Proteins Enzymes & Regulators
  3. Receptor Tyrosine Kinases Transferases (EC 2) Protein Tyrosine Kinases
  4. Trk Receptors TrkA
  5. TrkA 蛋白, Human (HEK293)

TrkA 蛋白, Human (HEK293)

目录号: HY-P7308
COA 产品使用指南

TrkA 蛋白, Human (HEK293)是神经营养素、神经生长因子的高亲和力催化受体,调节神经生长因子的多种作用,包括神经元分化和避免程序性细胞死亡。

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规格 价格 是否有货 数量
10 μg ¥1600 In-stock
50 μg ¥4000 In-stock
100 μg   询价  

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描述

TrkA Protein, Human (HEK293) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death.

研究背景

酪氨酸激酶受体 A (TrkA) 是神经营养蛋白、神经生长因子 (NGF) 的高亲和力催化受体,介导 NGF 的多种作用,包括神经元分化和避免程序性细胞死亡。TrkA 最初是从结肠肿瘤中克隆出来的;癌症是通过易位发生的,易位导致 TrkA 激酶结构域[1][2]激活。

生物活性

The ED50 is <1 μg/mL as measured by TF-1 cells.

种属

Human

表达系统

HEK293

标签

Tag Free

蛋白编号

P04629-1 (A34-P407)

基因 ID
蛋白结构
N-term
TrkA (A34-P407)
Accession # P04629
C-term
中文名
重组人酪氨酸激酶受体 A (HEK293细胞表达)
同用名
rHuTrkA; NTRK1; MTC; TRK
氨基酸序列

APCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTC

分子量

65-85 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against PBS.

内毒素含量

<0.2 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TrkA Protein, Human (HEK293)
目录号:
HY-P7308
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