1. 重组蛋白
  2. Receptor Proteins Enzymes & Regulators
  3. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. Trk Receptors TrkA
  5. TrkA 蛋白, Human (HEK293, His)

TrkA 蛋白, Human (HEK293, His)

目录号: HY-P73457
COA 产品使用指南

Pentraxin 3/TSG-14 蛋白是一种多功能蛋白,在免疫反应和炎症中发挥作用。它参与病原体的识别和清除以及炎症过程的调节。Pentraxin 3/TSG-14 蛋白的失调与多种疾病有关,包括心血管疾病和感染。靶向 Pentraxin 3/TSG-14 蛋白可能在这些情况下具有治疗潜力。TrkA 蛋白, Human (HEK293, His) 是重组的 TrkA 蛋白,由 HEK293 表达,带有 N-His 标签。TrkA 蛋白, Human (HEK293, His) 全长 220 个氨基酸,分子量为 35-60 kDa。

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规格 价格 是否有货 数量
Free Sample   Apply now  
5 μg ¥430 In-stock
10 μg ¥750 In-stock
50 μg ¥2060 In-stock
100 μg ¥3500 In-stock
500 μg ¥12000 In-stock
> 100 μg   询价  

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  • 生物活性

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描述

Pentraxin 3/TSG-14 protein is a multifunctional protein that plays a role in immune response and inflammation. It is involved in the recognition and clearance of pathogens, as well as regulation of inflammatory processes. Dysregulation of Pentraxin 3/TSG-14 protein has been associated with various diseases, including cardiovascular disorders and infections. Targeting Pentraxin 3/TSG-14 protein may hold therapeutic potential in these conditions. TrkA Protein, Human (HEK293, His) is the recombinant human-derived TrkA protein, expressed by HEK293 , with N-His labeled tag. The total length of TrkA Protein, Human (HEK293, His) is 220 a.a., with molecular weight of 35-60 kDa.

研究背景

TrkA 蛋白是神经营养酪氨酸激酶受体 (NTKR) 家族的成员,编码一种膜结合受体,在与神经营养蛋白结合后,启动其自身和 MAPK 通路成员的磷酸化。这种激酶的存在促进细胞分化,并可能在指定感觉神经元亚型中发挥作用。该基因的突变与先天性疼痛不敏感、无汗症、自残行为、认知障碍和癌症有关。该基因的几种替代转录剪接变体已被鉴定,但迄今为止仅对三种进行了表征。该基因表现出偏表达,在肾上腺 (RPKM 3.7)、睾丸 (RPKM 1.0) 和 10 个其他组织中检测到较高水平,表明其在多个器官的各种生理环境中具有潜在意义。

生物活性

Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 0.06643 μg/mL, corresponding to a specific activity is 1.51×10^4 units/mg.

种属

Human

表达系统

HEK293

标签

N-His

蛋白编号

NP_002520.2 (P194-E413)

基因 ID
蛋白结构
N-term
His
TrkA (P194-E413)
Accession # NP_002520.2
C-term
同用名
High affinity nerve growth factor receptor; Trk-A; NTRK1; MTC; TRK
氨基酸序列

PTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDE

分子量

35-60 kDa

纯度
  • Measured by its ability to inhibit NGF-induced proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 0.06643 μg/mL, corresponding to a specific activity is 1.51×104 units/mg.
性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TrkA Protein, Human (HEK293, His)
目录号:
HY-P73457
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