2. Apoptosis PROTAC
  3. RIP kinase PROTACs
  4. RIP2 Kinase Inhibitor 4

RIP2 Kinase Inhibitor 4，一种有效且选择性的 RIPK2 PROTAC，可有效降解 RIPK2 (pIC50 of 8) 并抑制相关 TNF-α 的释放。

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RIP2 Kinase Inhibitor 4 Chemical Structure

RIP2 Kinase Inhibitor 4 Chemical Structure

CAS No. : 2126803-41-4

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RIP2 Kinase Inhibitor 4 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α[1].

IC50 & Target[1]

cIAP1

 

RIPK2

8 (pIC50)

体外研究
(In Vitro)

RIP2 Kinase Inhibitor 4 (Compound 20) utilizes a novel inhibitor of apoptosis (IAP) binder. RIP2 Kinase Inhibitor 4 possess comparatively reduced binding potency at both cIAP1 and XIAP BIR3 domains and increased potency at the XIAP BIR2 domain[1].
RIP2 Kinase Inhibitor 4 (Compound 20) recruits the IAP E3 ligases and shows markedly reduced inhibition of muramyl dipeptide (MDP)-stimulated TNFα production in human peripheral blood mononuclear cells (PBMCs) (pIC50 of 9.3)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RIP2 Kinase Inhibitor 4 相关抗体:
体内研究
(In Vivo)

The initial in vivo assessment of RIP2 Kinase Inhibitor 4 (Compound 20) in rats dosed at 0.5 mg/kg SC demonstrated high levels of RIPK2 degradation and inhibition of MDP-stimulated TNFα release at the final 48 h time point[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1045.21

Formula

C50H66F2N14O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RIP2 Kinase Inhibitor 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIP2 Kinase Inhibitor 42126803-41-4RIP kinasePROTACsReceptor-interacting protein kinasesRIPKRIPK2PROTACTNF-αXIAPBIR2IAPInhibitorinhibitorinhibit

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产品名称：
RIP2 Kinase Inhibitor 4
目录号：
HY-136010
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