2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Ro 04-5595 hydrochloride

Ro 04-5595 hydrochloride 是一种 GluN2B 选择性的 NMDA 受体 拮抗剂 (Ki: 31 nM)。

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Ro 04-5595 hydrochloride Chemical Structure

Ro 04-5595 hydrochloride Chemical Structure

CAS No. : 64047-73-0

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Ro 04-5595 hydrochloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM)[1].

IC50 & Target[1]

GluN2B

31 nM (Ki)

体内研究
(In Vivo)

Ro 04-5595 hydrochloride (5-20 mg/kg，i.p.) 抑制 MA 诱导的小鼠中运动刺激[2]。
Ro 04-5595 hydrochloride (10mg/kg，i.p.，持续 6 天) 降低可卡因给药大鼠的 AMPA 与 NMDA 比率[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Methamphetamine (MA) treated mice[1]
Dosage: 3-30 mg/kg
Administration: i.p., given 30 min before injection of MA (2 mg/kg, i.p.)
Result: Dose-dependently decreased MA-induced locomotor activity.
分子量

368.30

Formula

C19H23Cl2NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ro 04-5595 hydrochloride 相关分类

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 04-559564047-73-0iGluRIonotropic glutamate receptorsGluN2BMethamphetamineAMPAlocomotorInhibitorinhibitorinhibit

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产品名称：
Ro 04-5595 hydrochloride
目录号：
HY-107696
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