1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
  2. PKA
  3. Rp-cAMPS sodium salt

Rp-cAMPS sodium salt 

目录号: HY-100530D
产品使用指南

Rp-cAMPS sodium salt,一种 cAMP 的类似物,是一种 cAMP 诱导的 PKA IPKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的,竞争性拮抗剂。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。

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Rp-cAMPS sodium salt Chemical Structure

Rp-cAMPS sodium salt Chemical Structure

CAS No. : 142439-94-9

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Description

Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

IC50 & Target

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1]

In Vitro

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2].

In Vivo

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2].

Molecular Weight

367.25

Formula

C₁₀H₁₁N₅NaO₅PS

CAS No.

142439-94-9

SMILES

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@@](OC2)([S-])=O)N3C4=C(C(N)=NC=N4)N=C3.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Rp-cAMPSPKAProtein kinase AcAMPmembrane-permeablesynapticneuronsPKA-IPKA-IIphosphodiesterasesresistantInhibitorinhibitorinhibit

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产品名称:
Rp-cAMPS sodium salt
目录号:
HY-100530D
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