1. Stem Cell/Wnt TGF-beta/Smad
  2. PKA
  3. Rp-cAMPS

Rp-cAMPS,一种 cAMP 的类似物,是一种 cAMP 诱导的 PKA IPKA II 活化 (Ki 分别为 12.5 µM 和 4.5 µM) 的有效的,竞争性拮抗剂。Rp-cAMPS 耐磷酸二酯酶水解。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Rp-cAMPS sodium saltRp-cAMPS triethylammonium salt 通常具有更好的水溶性和稳定性。

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Rp-cAMPS Chemical Structure

Rp-cAMPS Chemical Structure

CAS No. : 73208-40-9

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Rp-cAMPS 的其他形式现货产品:

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

IC50 & Target

Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1]

体外研究
(In Vitro)

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

345.27

Formula

C10H12N5O5PS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Rp-cAMPS 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Rp-cAMPS
目录号:
HY-100530A
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