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  4. Salicylate choline

Salicylate choline  (Synonyms: (2-羟乙基)三甲基铵水杨酸盐)

目录号: HY-W338346
产品使用指南 技术支持

Salicylate choline 是 Aspirin (acetylsalicylic acid) (HY-14654) 的衍生物，具有口服活性。Salicylate choline 可显著降低细胞中的 IL-1β、IL-6、TNF-α 和 IL-10 水平。Salicylate choline 通过诱导 S 期细胞周期停滞并损害 DNA 损伤修复，从而增强 CRM1 抑制剂 Selinexor (KPT-330) (HY-17536) 的抗肿瘤活性。Salicylate choline 与 Selinexor 联合在携带 JeKo-1 细胞的小鼠异种移植模型中显示出优秀的抗肿瘤功效。Salicylate choline 可用于风湿病、炎症和癌症的研究。

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Salicylate choline

Salicylate choline Chemical Structure

CAS No. : 2016-36-6

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Salicylate choline 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer[1][2][3][4].

体外研究
(In Vitro)

Salicylate choline (24 h) 在 HGF-1 细胞中显著降低 IL-1β、IL-6、TNF-α 和 IL-10 水平[1]。
Salicylate choline (2-3 mM, 48-72 h) 与 Selinexor (KPT-330) (HY-17536) 联合对血液系统恶性肿瘤细胞表现出强效抗增殖活性，包括 MCL (JeKo-1, Mino)、TCL (SR-786, Karpas-299)、DLBCL (OCI-Ly1, OCI-Ly3, OCI-Ly19, SU-DHL-6, RPMI)、MM (U266, OPM2, Xg1, KMS2)、WM (BCWM, MWCL)、ALL (RPCI, CRL-1783)，以及实体瘤细胞，包括胰腺癌 (Panc-1, L3.6pl)、非小细胞肺癌 (H460, A549, HCC827)、小细胞肺癌 (H1048)、肉瘤 (FuJi, SW872)、乳腺癌 (Hs 578T, BT-474, BT-20, MCF7)[4]。
Salicylate choline (3 mM, 24 h) 与 Selinexor 联合在 JeKo-1 细胞中显著下调 Rad51 和胸苷酸合酶 (TYMS) 表达，并增加 γ-H2AX (DNA 损伤标志物) 水平[4]。
Salicylate choline (3 mM, 24-48 h) 与 Selinexor 联合在双胸苷阻滞释放后显著抑制 OCI-Ly1 细胞 (DLBCL) 中 G2/M 期相关蛋白 (PLK1, Bub1b, Aurora A) 的表达[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Salicylate choline 相关抗体:

Cell Cycle Analysis[4]

Cell Line: OCI-Ly1 cells
Concentration: 3 mM combined with Selinexor
Incubation Time: 24, 36, 48 h
Result: Suppressed G2/M phase-related proteins (PLK1, Bub1b, Aurora A) expression in OCI-Ly1 cells.
体内研究
(In Vivo)

Salicylate choline (500 mg/kg，口服，每周连续 6 天，26 天) 与 Selinexor 联合在携带 JeKo-1 细胞的雄性小鼠异种移植模型中显示出卓越的抗肿瘤功效 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: JeKo-1 cells (5 × 106) were subcutaneously implanted into the flanks of 4-6 weeks old male NSG mice[4]
Dosage: 500 mg/kg combined with Selinexor (15 mg/kg, p.o., twice weekly, 26 days)
Administration: p.o., consecutively 6 days per week, 26 days
Result: Achieved significant tumor growth inhibition.
Showed no significant changes in body weight.
分子量

241.28

Formula

C12H19NO4
CAS 号
中文名称

(2-羟乙基)三甲基铵水杨酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Salicylate choline 相关分类

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Keywords:

Salicylate2016-36-6(2-羟乙基)三甲基铵水杨酸盐Drug DerivativeInterleukin RelatedTNF ReceptorPolo-like Kinase (PLK)Drug derivativeILTumor Necrosis Factor ReceptorTNFRJeKo-1 cellsIL-1βIL-6TNF-αrheumatic diseasesinflammationcancerInhibitorinhibitorinhibit

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