2. Apoptosis
  3. Apoptosis
  4. Sappanchalcone

Sappanchalcone 从 Caesalpinia sappan L. 中提取的黄酮类化合物，诱导人结肠癌细胞凋亡 (apoptosis)。

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Sappanchalcone Chemical Structure

Sappanchalcone Chemical Structure

CAS No. : 94344-54-4

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规格 价格 是否有货 数量
1 mg ￥3500
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5 mg ￥9800
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Sappanchalcone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].

体外研究
(In Vitro)

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sappanchalcone 相关抗体:
分子量

286.28

Formula

C16H14O5
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Sappanchalcone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sappanchalcone94344-54-4ApoptosisflavonoidHCT116cellscoloncancerphosphorylationInhibitorinhibitorinhibit

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