1. 一站式药筛
  2. 化合物库
  3. 硼酸/硼酸酯类片段化合物库
硼酸/硼酸酯类片段化合物库 - Boronic acid/boronic ester fragment library

Cat. No.: HY-L924

在药物设计中,硼酸/硼酸酯是一种比较新颖且有潜力的化学结构。硼酸以sp²杂化状态存在,其分子有一个空的p轨道,可以作为Lewis酸接受杂原子(O,N或S)的孤对电子,这一独特的Lewis酸特性,使其能够与靶蛋白上的特定氨基酸残基(如赖氨酸、丝氨酸、苏氨酸、组氨酸等)形成可逆的共价键。目前FDA已批准的5个硼酸或硼酸酯药物,与靶蛋白的作用大都涉及共价结合机制。此外,硼酸还可以作为羧酸、磷酸和酚基的电子等排体,用于改善药代动力学特征和提高药效。

迄今为止,已有5个含硼药物被FDA批准上市。硼酸/硼酸酯的特性让它在药物设计中拥有极大的潜力,已应用到癌症治疗(如多发性骨髓瘤)、抗感染(如真菌感染、结核病)、抗炎症(如特应性皮炎)、抗细菌(如碳青霉烯类耐药细菌感染)和活性氧(Reactive Oxygen Species, ROS) 响应型前药等领域。MCE硼酸/硼酸酯片段化合物库含有1600多个化合物,是用于开发含硼类药物的有用工具。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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  • 生物活性
  • 产品详情

活性描述 & 特点

Biological Activity

•    A unique collection of 1600 boronic acid/boronic ester fragment compounds is available for high throughput screening (HTS) and high content screening (HCS).

•    All compounds are screened using substructure search.

•   All compounds are available off the shelf.

•   LCMS or NMR validated to ensure high purity and quality.

产品详情

Product Details

Formulation:

1600+ boronic acid or boronic ester compounds obtained through substructure search, making it a valuable tool for the discovery of boron-containing drugs.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Boronic acid/boronic ester fragment library
    目录号:
    HY-L924
    需求量: