2. Inhibitory Antibodies
  3. Setrusumab

Setrusumab  (Synonyms: BPS 804)

目录号: HY-P99398

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Setrusumab (BPS 804) 是一种靶向硬化蛋白 (sclerostin) 的完全人源单克隆抗体。Setrusumab 有效改善骨强度。Setrusumab 可用于成骨不全症 (OI) 和癌症的研究。

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Setrusumab Chemical Structure

Setrusumab Chemical Structure

CAS No. : 1847394-95-9

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Setrusumab 相关抗体

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  • 生物活性

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生物活性

Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer[1].

体内研究
(In Vivo)

Setrusumab (100 mg/kg；每周一次，静脉注射，持续 4 周) 抑制小鼠乳腺癌诱导的骨转移和肌肉无力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old female immune-compromised CB-17/lcr-Prkdcscid/Rj mice with MDA-MB-231 breast cancer cells injection[1]
Dosage: 100 mg/kg
Administration: Intravenous injection; 100 mg/kg once a week for 4 weeks
Result: Significantly inhibited tumor growth in bones and breast cancer cell dissemination into other organs. Inhibited breast cancer-induced osteolytic lesions and subsequent loss of bone mass of the distal femur and of the proximal tibia. Redued phosphorylation of IKKα, IKKβ, and p65.
Clinical Trial
CAS 号
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Keywords:

Setrusumab1847394-95-9BPS 804BPS804BPS-804Othersmonoclonal antibodyOIcancerbone metastasemuscle weaknessInhibitorinhibitorinhibit

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