2. Epigenetics
  3. Histone Methyltransferase
  4. SGC0946 TFA

SGC0946 TFA 是一种选择性的 DOT1L 抑制剂，其 IC50 值为 0.3 nM。SGC0946 TFA 可通过抑制 DOT1L，诱导癌细胞 G1 期停滞，以及抑制细胞的自我更新和转移潜力，并诱导细胞分化。SGC0946 TFA 可用于白血病和乳腺癌等肿瘤的研究，也可作为探针以进一步研究 DOT1L 在正常和病变细胞中的细胞机制。

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SGC0946 TFA

SGC0946 TFA Chemical Structure

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SGC0946 TFA 的其他形式现货产品:

Customer Review

Other Forms of SGC0946 TFA:

SGC0946 TFA 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SGC0946 TFA is a selective DOT1L inhibitor with an IC50 value of 0.3 nM. By inhibiting DOT1L, SGC0946 TFA can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 TFA can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells[1][2][3].

IC50 & Target[1]

DOT1L

0.3 nM (IC50)

分子量

732.59

Formula

C30H41BrF3N7O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SGC0946 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGC0946SGC 0946SGC-0946Histone MethyltransferaseleukemiaMLL-rearrangeovarian cancerMolm13 MLLcord blood cellsSK-OV-3TOV21GInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-15650A
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