2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Topoisomerase Cytochrome P450
  4. Simmitecan hydrochloride

Simmitecan hydrochloride 是一种 9-取代的亲脂性喜树碱 (Camptothecin (HY-16560)) 衍生物，是一种有效的拓扑异构酶 I (topoisomerase I) 抑制剂。Simmitecan hydrochloride 是一种抗癌剂。

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Simmitecan hydrochloride Chemical Structure

Simmitecan hydrochloride Chemical Structure

CAS No. : 1247847-78-4

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Simmitecan hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin (HY-16560) derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].

体外研究
(In Vitro)

Simmitecan hydrochloride 对 CYP2D6 有弱抑制作用 (IC50: 32.9 μM)，对 CYP3A4 有中等抑制作用 (IC50: 8.95 μM)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Simmitecan hydrochloride 相关抗体:
体内研究
(In Vivo)

Simmitecan hydrochloride (3.75、7.5 和 15 mg/kg, SD 大鼠, 静脉推注) 显示平均消除半衰期 t1/2 约为 1.4 小时[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

635.15

Formula

C34H39ClN4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Simmitecan hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Simmitecan1247847-78-4TopoisomeraseCytochrome P450CYPsCancerCamptothecintopoisomeraseInhibitorinhibitorinhibit

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产品名称：
Simmitecan hydrochloride
目录号：
HY-107133
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