2. Epigenetics Autophagy
  3. Histone Methyltransferase Autophagy
  4. SMYD3-IN-2

SMYD3-IN-2 是一种 SMYD3 抑制剂，可通过诱导致死性自噬来对抗胃癌。SMYD3-IN-2 对 SMYD3 和 BGC823 细胞具有抑制作用，IC50 值分别为 0.81 μM 和 0.75 μM。SMYD3-IN-2 可用于癌症的研究。

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SMYD3-IN-2 Chemical Structure

SMYD3-IN-2 Chemical Structure

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SMYD3-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer[1].

IC50 & Target

SMYD3

0.81 μM μM (IC50)

体外研究
(In Vitro)

SMYD3-IN-2 (compound 7r) (1.0 μM) 对 SMYD3 和 BGC823 细胞表现出强效抑制能力，IC50 值分别为 0.81 μM和 0.75 μM[1] .
SMYD3-IN-2 (1.0 μM; 24 h) 可抑制 SMYD3 引起的 Akt 甲基化和激活[1]。
SMYD3-IN-2 (0-48 h) 通过诱导自噬性细胞死亡抑制 BGC823 胃腺癌细胞的增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SMYD3-IN-2 相关抗体:

Western Blot Analysis[1]

Cell Line: BGC823 cells
Concentration: 1.0 μM
Incubation Time: 24 h
Result: Suppressed the methylation levels of H3K4 and could significantly inhibit the lysine methylation of Akt1 by SMYD3.
体内研究
(In Vivo)

SMYD3-IN-2 (compound 7r) (i.p.; 15 and 30 mg/kg) suppresses the growth of BGC823 xenograft models in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xenograft Balb/c nude mice models[1]
Dosage: 15 and 30 mg/kg
Administration: Intraperitoneally administration
Result: Remarkably suppressed the tumor volume, tumor weight and growth curves of gastric cancer xenografts in a dose-dependent manner.
Resulted in strong immunohistochemistry staining of LC3-II and p62, weak staining of p-Akt (T308) and Ki67.
分子量

505.36

Formula

C26H21BrN2O4
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SMYD3-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMYD3-IN-2Histone MethyltransferaseAutophagySMYD3programmed cell deathgastric cancerautophagyBGC823 cellInhibitorinhibitorinhibit

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