1. Stem Cell/Wnt TGF-beta/Smad
  2. PKA
  3. Sp-8-CPT-cAMPS

Sp-8-CPT-cAMPS,一种 cAMP 类似物,是 cAMP 依赖性蛋白激酶 A PKA IPKA II 的有效和选择性的激活剂。Sp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。

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Sp-8-CPT-cAMPS Chemical Structure

Sp-8-CPT-cAMPS Chemical Structure

CAS No. : 129693-13-6

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold[1][2].

IC50 & Target

PKA[1]

体外研究
(In Vitro)

Sp-8-CPT-cAMPS (100 μM; 24 h) enhances the IL-1β-stimulated nitrite release, and increases the release ofnitrite by vascular smooth muscle cells by 3 fold in the absence of IL-1β in vascular smooth muscle cells[2].
Sp-8-CPT-cAMPS (100 μM; 24 h) increases IL-1β-induced expression of iNOS protein in rat aortic smooth muscle cells[2].
Sp-8-CPT-cAMPS (10 μM; 30 min) exhibits anti-spasmogenic activity on ACh-induced tension development in guinea-pig trachealis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

487.88

Formula

C16H15ClN5O5PS2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Sp-8-CPT-cAMPS 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Sp-8-CPT-cAMPS
目录号:
HY-120994B
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