2. Protein Tyrosine Kinase/RTK
  3. Src
  4. Squarunkin A hydrochloride

Squarunkin A hydrochloride 是一种有效的选择性 UNC119-内容物 (Cargo) 相互作用抑制剂，抑制 UNC119A 与肉豆蔻酰化的 Src N 末端肽相互作用 (IC50=10 nM)。Squarunkin A hydrochloride 会干扰细胞中 Src 激酶的活化。

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Squarunkin A hydrochloride Chemical Structure

Squarunkin A hydrochloride Chemical Structure

CAS No. : 2253744-55-5

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Squarunkin A hydrochloride 的其他形式现货产品:

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Squarunkin A hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Squarunkin A hydrochloride is a potent and selective UNC119-cargo interaction inhibitor (IC50 of 10 nM for inhibiting the UNC119A-myristoylated Src N-terminal peptide interaction). Squarunkin A hydrochloride interferes with the activation of Src kinase in cells[1].

IC50 & Target

IC50: 10 nM (UNC119A-myristoylated Src N-terminal peptide interaction)[1]
体外研究
(In Vitro)

Squarunkin A (2.5 μM, 0.625 μM, 0.078 μM, and 0.01 μM) treatment leads to a concentration-dependent reduction of Src phosphorylation[1].
Squarunkin A does not target the lipoprotein-binding sites of other lipoprotein chaperones, such as PDE6d, AIPL1, and RhoGDI, which bind S-prenylated proteins. Squarunkin A binds to UNC119 in cell lysate and interferes with Src activation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Squarunkin A hydrochloride 相关抗体:
分子量

560.01

Formula

C25H33ClF3N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Squarunkin A hydrochloride 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Squarunkin A2253744-55-5SrcUNC119AN-terminalmyristoylatedlipidatedphosphorylationInhibitorinhibitorinhibit

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目录号：
HY-127002A
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