2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. SR31527 chloride

SR31527 chloride 是一种有效的 KIFC1 抑制剂，IC50 值为 6.6 µM。SR31527 chloride 降低细胞活力和集落形成。

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SR31527 chloride Chemical Structure

SR31527 chloride Chemical Structure

CAS No. : 311814-78-5

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SR31527 chloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SR31527 chloride is a potent KIFC1 inhibitor with an IC50 value of 6.6 µM. SR31527 chloride decreases cell viability and colony formation[1].

IC50 & Target

IC50: 6.6 µM (KIFC1)[1]
体外研究
(In Vitro)

SR31527 chloride 与 KIFC1 结合，Kd 值为 25.4 nM[1]。
SR31527 chloride (50 µM；24 小时) 在 MDA-MB-231、BT549 和 MDA-MB-435s 细胞中诱导多纺锤体形成[1]。
SR31527 chloride (0-100 µM；96 小时，10-12 天) 降低乳腺癌细胞的细胞活力和集落形成，并且对 LL47 细胞的细胞毒性较小[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SR31527 chloride 相关抗体:

Cell Viability Assay[1]

Cell Line: MDA-MB-231, BT549, MDA-MB-435s cells
Concentration: 0-100 µM
Incubation Time: 96 h
Result: Decreased cell viability with IC50s of 29, 33, 20 µM for MDA-MB-231, BT549, MDA-MB-435s cells, respectively.
分子量

319.81

Formula

C15H14ClN3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SR31527 chloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR31527311814-78-5SR 31527SR-31527KinesinantiproliferativeMDA-MB-231BT549MDA-MB-435s cellsLL47 cellsanticancerInhibitorinhibitorinhibit

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HY-118961
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