1. Antibody-drug Conjugate/ADC Related
  2. Drug-Linker Conjugates for ADC
  3. Stabilized lactone

Stabilized lactone 

目录号: HY-128942
产品使用指南

Stabilized lactone (Drug linker 2) 是一种稳定的内酯化合物,由 ADC 毒物 SN-38 和 linker 组成。Stabilized lactone 对 L540cy 细胞和 Ramos 细胞具有细胞毒性,IC50 分别为 99 和 105 ng/mL。

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Stabilized lactone Chemical Structure

Stabilized lactone Chemical Structure

CAS No. : 2246380-70-9

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Description

Stabilized lactone (Drug linker 2) is a stabilized lactone-linked SN-38 drug linker. Stabilized lactone is cytotoxic across L540cy cells and Ramos cells with IC50 values of 99 and 105 ng/mL, respectively[1].

Molecular Weight

1091.06

Formula

C₅₀H₅₄N₆O₂₀S

CAS No.

2246380-70-9

SMILES

O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(COC(N(CO[C@](C3=C(CO4)C(N5CC6=C(CC)C7=CC(O)=CC=C7N=C6C5=C3)=O)(CC)C4=O)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Stabilized lactone
目录号:
HY-128942
需求量:

Stabilized lactone

Cat. No.: HY-128942