1. Immunology/Inflammation
  2. STING
  3. C-178

C-178 

目录号: HY-123963
产品使用指南

C-178,STING 的共价抑制剂,与 Cys91 有效结合并选择性地抑制小鼠中不同的激活剂引起的 STING 反应。C-178 选择性地降低 STING- 而非 RIG-I- 或 TBK1- 介导的 IFN-β 报告基因活性。C-178 阻断棕榈酰化 (PMA) 诱导的 STING 类聚;抑制 CMA 诱导的 TBK1 (STING 下游蛋白激酶) 磷酸化。

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C-178 Chemical Structure

C-178 Chemical Structure

CAS No. : 329198-87-0

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Description

C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1].

IC50 & Target

STING[1]

Molecular Weight

322.27

Formula

C₁₇H₁₀N₂O₅

CAS No.

329198-87-0

SMILES

O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C3C(OC4=CC=CC=C34)=C2

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
C-178
目录号:
HY-123963
需求量:

C-178

Cat. No.: HY-123963