2. Stem Cell/Wnt
  3. YAP
  4. TAT-PDHPS1

TAT-PDHPS1 是一种 YAP 抑制剂，由内源性肽 PDHPS1 和细胞穿透肽序列 TAT 组成。PDHPS1 可与蛋白磷酸酶2A （PP2A）的必需激活因子蛋白磷酸酶2磷酸酶激活因子（protein phosphatase 2 phosphatase activator， PTPA）结合，导致 YAP 磷酸化水平升高，进而使 YAP 失活，抑制其下游靶基因的表达。TAT-PDHPS1 可用于卵巢癌的研究。

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TAT-PDHPS1

TAT-PDHPS1 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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规格 是否有货
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Customer Review

TAT-PDHPS1 相关抗体

Top Publications Citing Use of Products

查看 YAP 亚型特异性产品:

查看所有亚型
YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TAT-PDHPS1 is a YAP inhibitor composed of the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), leading to increased YAP phosphorylation, which inactivates YAP and suppresses the expression of its downstream target genes. TAT-PDHPS1 is potentially useful in ovarian cancer research[1].

分子量

3744.28

Formula

C156H280N62O45
Sequence

Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-Gln-Ile-Ala-Thr-Thr-Thr-Ala-Ser-Ala-Ala-Thr-Ala-Ala-Ala-Ile-Gly-Ala-Thr-Pro-Arg-Ala-Lys
Sequence Shortening

GRKKRRQRRRPPQQIATTTASAATAAAIGATPRAK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TAT-PDHPS1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-PDHPS1YAPYes-associated proteinInhibitorPDHPS1PP2Ainhibitorinhibit

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产品名称：
TAT-PDHPS1
目录号：
HY-P11219
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