1. GPCR/G Protein
    Neuronal Signaling
    Apoptosis
    Anti-infection
  2. Melanocortin Receptor
    Apoptosis
    Antibiotic
  3. Terrein

Terrein (Synonyms: 土曲霉酮)

目录号: HY-119808
产品使用指南

Terrein 是一种黑色素生成抑制剂。Terrein 诱导乳腺癌细胞凋亡 (apoptosis)。Terrein是铜绿假单胞菌 (Pseudomonas aeruginosa) 中的群体感应和 c-di-GMP 抑制剂。

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Terrein Chemical Structure

Terrein Chemical Structure

CAS No. : 582-46-7

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  • 生物活性

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  • 参考文献

生物活性

Terrein is a melanogenesis inhibitor[1]. Terrein induces apoptosis in breast cancer cell lines [2]. Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa[3].

体外研究
(In Vitro)

Treatment of Mel-Ab cells with Terrein (10-100 µM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation[1].
Terrein (5-500 µM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners[2].
Terrein (150, 250, 500µM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 µM) were used for subsequent experiments[2].
Terrein (25 and 75 µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 µM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells[2].
Terrein (75 µM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 µM) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells[2].
Terrein (10, 30, and 100 μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 5, 25, 50, 75, 100, 150, 250, 500 µM
Incubation Time: 24 and 48 hours
Result: The IC50s for MCF-7 and MDA-MB-231 cells after 24 h of incubation were 2.34 mM and 700 µM, respectively. After 48 h of incubation, the IC50s are 244.3 µM for MCF-7 and 244.5 µM for MDA-MB-231 cells.

Apoptosis Analysis[2]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 25, 75, 150, 250, 500 µM
Incubation Time: 24 hours
Result: The percentages of apoptotic cells after 25 and 75 µM treatment were 7.52 and 5.82%, respectively for MCF-7 cells (9.94% for the control), and 15.77 and 15.82%, respectively for MDA-MB-231 cells (8.79% for the control).

RT-PCR[2]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 25, 75 µM
Incubation Time:
Result: Decreased the mRNA levels of both MMP-2 and MMP-9 in a concentration-dependent manner.

Western Blot Analysis[2]

Cell Line: MCF-7 and MDA-MB-231 cells
Concentration: 75 µM
Incubation Time: 6, 12 and 24 hours
Result: RhoA and RhoB protein levels were significantly decreased after 6 h of 75 µM treatment in MCF-7 cells.
Phosphorylated (p)-Rac1 was also slightly decreased at 12 h. However, RhoC and Cdc42 levels remained unchanged. RhoB protein levels and Rac1 phosphorylation were also decreased in MDA-MB-231 cells at 12 and 24 h, respectively.
分子量

154.16

Formula

C₈H₁₀O₃

CAS 号
中文名称

土曲霉酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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