2. GPCR/G Protein Neuronal Signaling Autophagy PI3K/Akt/mTOR
  3. Adrenergic Receptor Atg8/LC3 Akt mTOR
  4. Tetrahydroalstonine

Tetrahydroalstonine  (Synonyms: 四氢鸭脚木碱; (-)-Tetrahydroalstonine)

目录号: HY-N1163 纯度: 99.84%
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Tetrahydroalstonine ((-)-Tetrahydroalstonine) 是一种吲哚生物碱和选择性的 α2-肾上腺素受体拮抗剂。Tetrahydroalstonine 具有一定的神经保护作用，可通过激活 Akt/mTOR 通路调控自噬-溶酶体功能，显著减轻 OGD/R 诱导的原代皮层神经元损伤。

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Tetrahydroalstonine Chemical Structure

Tetrahydroalstonine Chemical Structure

CAS No. : 6474-90-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5280
In-stock
1 mg ￥1950
In-stock
5 mg ￥4800
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

Tetrahydroalstonine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury[1][2][3].

体外研究
(In Vitro)

Tetrahydroalstonine (0.75-3 µM; 3-26 h) 在氧糖剥夺/复氧 (OGD/R) 处理的原代皮层神经元中提高了细胞活力，改善了自噬和溶酶体标志物 (LC3B-II/I、LAMP1、CSTB、TFEB) 的异常表达。机制涉及对 Akt/mTOR 通路的激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrahydroalstonine 相关抗体:

Cell Viability Assay[1]

Cell Line: OGD/R treated cortical neurons
Concentration: 0.75, 1.5 and 3 µM
Incubation Time: Pretreated with 2 h, then co-incubation for 24 h
Result: Increased the cell viability of cortical neurons.
体内研究
(In Vivo)

Tetrahydroalstonine (0.5-4 mg/kg; 静脉注射; 单剂量) 在去皮层大鼠中表现为低剂量 (0.5-2 mg/kg) 增强电刺激交感神经诱导的升压反应，高剂量 (4 mg/kg) 抑制该反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats were pithed and artificially ventilated with vagus nerve sectioning
Dosage: 0.5, 1, 2 and 4 mg/kg
Administration: Intravenous injection (i.v.); single dose
Result: Significantly potentiated the pressor response to electrical stimulation of sympathetic outflow (shown as negative inhibition) at low doses (0.5-2 mg/kg), while 4 mg/kg significantly reduced this response (PN50: 2.8 mg/kg). The potentiation at low doses suggested blockade of presynaptic α₂-adrenoceptors, leading to increased noradrenaline release.
分子量

352.43

Formula

C21H24N2O3
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

四氢鸭脚木碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (283.74 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8374 mL 14.1872 mL 28.3744 mL
5 mM 0.5675 mL 2.8374 mL 5.6749 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Tetrahydroalstonine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8374 mL 14.1872 mL 28.3744 mL 70.9361 mL
5 mM 0.5675 mL 2.8374 mL 5.6749 mL 14.1872 mL
10 mM 0.2837 mL 1.4187 mL 2.8374 mL 7.0936 mL
15 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7291 mL
20 mM 0.1419 mL 0.7094 mL 1.4187 mL 3.5468 mL
25 mM 0.1135 mL 0.5675 mL 1.1350 mL 2.8374 mL
30 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3645 mL
40 mM 0.0709 mL 0.3547 mL 0.7094 mL 1.7734 mL
50 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.4187 mL
60 mM 0.0473 mL 0.2365 mL 0.4729 mL 1.1823 mL
80 mM 0.0355 mL 0.1773 mL 0.3547 mL 0.8867 mL
100 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7094 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydroalstonine6474-90-4(-)-Tetrahydroalstonine四氢鸭脚木碱Adrenergic ReceptorAtg8/LC3AktmTORBeta ReceptorAutophagy-related 8PKBProtein kinase BMammalian target of RapamycinIndolealkaloidRhazyastrictaalpha2-adrenoceptorcortical neuronsInhibitorinhibitorinhibit

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