2. Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. Monoamine Oxidase Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family Cholinesterase (ChE)
  4. TFSeB

TFSeB 是一种神经保护剂。TFSeB 可降低 STZ (HY-13753) 诱导的 MAO-B 和AChE 活性。TFSeB 通过增加 BCL-2、BDNF、NRF2 的表达和降低 BAX 的表达来发挥神经保护作用。TFSeB 可以降低脂质过氧化 (TBARS) 和活性氧 (ROS) 水平。TFSeB 可以减轻神经炎症。TFSeB 可用于阿尔茨海默病的研究。

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TFSeB Chemical Structure

TFSeB Chemical Structure

CAS No. : 3017240-62-6

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TFSeB 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TFSeB is a neuroprotective agent. TFSeB can reduce Streptozotocin (STZ) (HY-13753) induced MAO-B and AChE activity. TFSeB exerts neuroprotective effects by increasing the expression of BCL-2, BDNF, NRF2, and decreasing the expression of BAX. TFSeB can reduce lipid peroxidation (TBARS) and reactive oxygen species (ROS) levels. TFSeB can reduce neuroinflammation. TFSeB can be used for research on Alzheimer’s disease[1].

IC50 & Target

Bcl-2

 

AChE

 

Bax

 

体内研究
(In Vivo)

TFSeB (1 mg/kg 或 5 mg/kg；i.g.；每日一次；持续 20 天) 可以在雄性 Swiss 小鼠体内发挥神经保护作用，改善认知障碍，减少氧化应激和神经炎症，调节神经递质相关酶的活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (25-35 g) received intracerebroventricular injections of Streptozotocin (STZ) (HY-13753) (3 mg/kg)[1]
Dosage: 1 mg/kg or 5 mg/kg
Administration: Oral gavage (i.g.); once daily for 20 days
Result: Significantly improved STZ-induced spatial working memory deficits.
Restored short-term and long-term recognition memory in the mice with an Alzheimer’s disease.
Significantly reduced MAO-B activity as a MAO-B modulator.
Significantly reversed AChE activity in the STZ mice.
Improved oxidative stress levels, including a reduction in TBARS, ROS, NOx, and NPSH levels.
Upregulated the levels of BDNF, NRF2 and BCL-2 and downregulated the levels of NF-κB, IL-6, CAT, SOD, GSk3B and BAX.
Did not cause liver, kidney toxicity or metabolic abnormalities.
分子量

357.23

Formula

C16H13F3OSe
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TFSeB 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TFSeB3017240-62-6Monoamine OxidaseReactive Oxygen Species (ROS)NF-κBBcl-2 FamilyCholinesterase (ChE)MAONuclear factor-κBNuclear factor-kappaBMAO-BAChEBCL-2ROSneuroinflammationInhibitorinhibitorinhibit

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