2. Immunology/Inflammation
  3. COX
  4. Tinoridine

Tinoridine  (Synonyms: Y-3642)

目录号: HY-W032848 纯度: 99.00%
COA 产品使用指南

摩尔计算器

Tinoridine (Y-3642) 是一种具有口服活性的非甾体抗炎剂，具有强大的抗氧化能力和自由基清除活性。Tinoridine 通过抑制 COX 酶而发挥作用，参与抑制肝毒性。

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Tinoridine Chemical Structure

Tinoridine Chemical Structure

CAS No. : 24237-54-5

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规格 价格 是否有货 数量
5 mg ￥267
In-stock
10 mg ￥400
In-stock
25 mg ￥640
In-stock
50 mg ￥960
In-stock
100 mg ￥1440
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Tinoridine 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. [1][2][3].

体外研究
(In Vitro)

Tinoridine (10-100 μM) exerts effect on stability of rat liver and kidney lysosomes, and liver parenchymal cells[3].
Tinoridine (1, 10, and 100 μM; 30 min) inhibits spontaneous release of acid phosphatase from liver lymomoses in vitro[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tinoridine 相关抗体:
体内研究
(In Vivo)

Tinoridine (100 mg/kg; p.o.; single dose) inhibits CCl4 hepatotoxicity in rats, with a strong control of the CCl4-induced enzyme activities[2].
Tinoridine (100 mg/kg; i.p.; single dose) protects the stability of rat liver and kidney lysosomes in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (180-220 g)[2]
Dosage: 100 mg/kg
Administration: Oral gavage; single dose; 1 hour before CCl4 (i.p.; 0.25 mL/kg) treatment
Result: Inhibited the CCl4-induced enzyme activities increase of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and also rescued the liver microsomal cytochrome P-450 and glucose-6-phosphatase activities.
Clinical Trial
分子量

316.42

Formula

C17H20N2O2S
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (395.04 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1604 mL 15.8018 mL 31.6036 mL
5 mM 0.6321 mL 3.1604 mL 6.3207 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Tinoridine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1604 mL 15.8018 mL 31.6036 mL 79.0089 mL
5 mM 0.6321 mL 3.1604 mL 6.3207 mL 15.8018 mL
10 mM 0.3160 mL 1.5802 mL 3.1604 mL 7.9009 mL
15 mM 0.2107 mL 1.0535 mL 2.1069 mL 5.2673 mL
20 mM 0.1580 mL 0.7901 mL 1.5802 mL 3.9504 mL
25 mM 0.1264 mL 0.6321 mL 1.2641 mL 3.1604 mL
30 mM 0.1053 mL 0.5267 mL 1.0535 mL 2.6336 mL
40 mM 0.0790 mL 0.3950 mL 0.7901 mL 1.9752 mL
50 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5802 mL
60 mM 0.0527 mL 0.2634 mL 0.5267 mL 1.3168 mL
80 mM 0.0395 mL 0.1975 mL 0.3950 mL 0.9876 mL
100 mM 0.0316 mL 0.1580 mL 0.3160 mL 0.7901 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tinoridine24237-54-5Y-3642Y3642Y 3642COXCyclooxygenasespontaneous releaseliverkidneylysosomesparenchymal cellshepatotoxicityradical scavenger activitynonsteroidal anti-inflammatory agentNAIADInhibitorinhibitorinhibit

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