2. GPCR/G Protein
  3. Prostaglandin Receptor Angiotensin Receptor
  4. Tranilast sodium

Tranilast sodium  (Synonyms: 曲尼司特钠; MK-341 sodium; SB 252218 sodium)

目录号: HY-B0195A
产品使用指南

摩尔计算器

Tranilast sodium (MK-341 sodium) 是一种抗变态反应剂。抑制前列腺素 D2 产生 (PGD2，IC50=0.1 mM)。具有抗炎和免疫调节作用。Tranilast sodium 拮抗血管紧张素 II (angiotensin II) 并抑制其在血管平滑肌细胞中的生物学作用。

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Tranilast sodium Chemical Structure

Tranilast sodium Chemical Structure

CAS No. : 104931-56-8

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10 mg
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50 mg
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Other Forms of Tranilast sodium:

Tranilast sodium 相关抗体

Top Publications Citing Use of Products

    Tranilast sodium purchased from MCE. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.  [Abstract]

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

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    AT1 Receptor AT2 Receptor

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tranilast sodium (MK-341 sodium) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects[1]. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells[2].

    IC50 & Target

    Angiotensin II

     

    体外研究
    (In Vitro)

    Tranilast exhibits significant immunomodulatory activity inhibiting Endotoxin-induced prostaglandin E2 (PGE2; IC50=~1-20 μM), thromboxane B2 (IC50=~10-50 μM), (TGF-β1; IC50=~100-200 μM), and IL-8 (IC50=~100 μM) formation. A23187-induced monocyte leukotriene C4 or PGE2 formation is inhibited by Tranilast at IC50s of 10-40 μM and 2-20 μM, respectively[3].
    Tranilast (10-200 μM) exhibits the anti-proliferative effect in a dose-dependent manner in both MCF-7 and MDA-MB-231 cell lines. Tranilast also (10-200μM) enhances the anti-tumor effects of Tamoxifen (1-20 μM) on human breast cancer cells in vitro[4].
    Tranilast (12.5, 25, 50, 100 μg/mL; 72 hours) inhibits proliferation of HDMECs[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Tranilast sodium 相关抗体:

    Cell Proliferation Assay[4]

    Cell Line: MCF-7 and MDA-MB-231 cells
    Concentration: 10, 20, 50, 100, and 200 μM
    Incubation Time: 48 hours
    Result: Anti-proliferative effect in a dose-dependent manner in both cell lines.

    Cell Proliferation Assay[5]

    Cell Line: Human dermal microvascular endothelial cells (HDMECs)
    Concentration: 12.5, 25, 50, 100 μg/mL
    Incubation Time: 72 hours
    Result: IC50 value was 44.3 μg/mL (136 μM).
    体内研究
    (In Vivo)

    Tranilast (300 mg/kg; administered orally twice a day for 3 days) dose-dependently suppresses angiogenesis in mice[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Nine-week-old male C57BL/6 mice[5]
    Dosage: 300 mg/kg
    Administration: Administered orally twice a day for 3 days
    Result: Suppressed the VEGF-induced angiogenesis in matrigel; 58% of significant suppression was observed at a dose of 300 mg/kg.
    The ED50 value and 95% confidence limits were 165 mg/kg and 162±169 mg/kg, respectively.
    Clinical Trial
    分子量

    349.31

    Formula

    C18H16NNaO5
    CAS 号
    中文名称

    曲尼司特钠
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Tranilast sodium 相关分类

    • 摩尔计算器

    • 稀释计算器

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tranilast104931-56-8MK-341SB 252218曲尼司特钠MK341MK 341SB252218SB-252218Prostaglandin ReceptorAngiotensin Receptorangiogenesismicrovascularendothelialvasculargrowthfactorproliferationchemotaxistubeprostaglandinanti-atopicInhibitorinhibitorinhibit

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