1. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  2. ADC Cytotoxin Microtubule/Tubulin
  3. Tubulysin D

Tubulysin D  (Synonyms: 微管蛋白抑制剂 D)

目录号: HY-N2348
产品使用指南

Tubulysin D 是具有高细胞毒性的抗微管毒素 (anti-microtubule toxins),作为 ADC 细胞毒素 (ADC Cytotoxin) 合成 ADC。Tubulysin D 能够从粘细菌 Archangium geophyraAngiococcus disciformis 中分离得到。Tubulysin D 在哺乳动物细胞中显示出极其有效的细胞毒活性,包括多药耐药细胞系,IC50 值在较低的纳摩尔范围内。Tubulysin D 可抑制微管蛋白 (Microtubule/Tubulin) 聚合并导致细胞周期停滞和凋亡 (apoptosis)。

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Tubulysin D Chemical Structure

Tubulysin D Chemical Structure

CAS No. : 309935-57-7

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  • 生物活性

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生物活性

Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

IC50 & Target

IC50: 1.7 μM (Tubulin)[1]

体外研究
(In Vitro)

Tubulysin D has IC50s of 4.7 pM, 3.1 pM, 670 pM and 13 pM for HL60, HCT116, MCF7, A549 cell lines antiproliferative activity, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

828.07

Formula

C43H65N5O9S

CAS 号
中文名称

微管蛋白抑制剂 D

结构分类
初始来源

Archangium geophyra、Angiococcus disciformis

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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