1. 诱导疾病模型产品 Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. 心血管系统疾病模型 Reactive Oxygen Species Endogenous Metabolite
  3. 高血压模型
  4. Uric acid sodium

Uric acid sodium  (Synonyms: 尿酸钠; Monosodium urate)

目录号: HY-B2130A 纯度: 99.92%
COA 产品使用指南

Uric acid sodium (Monosodium urate) 是氧自由基 (oxygen radical) 的清除剂,是一种非常重要的抗氧化剂,有助于维持血压的稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS),如单线态氧和过氧亚硝酸盐,抑制脂质过氧化。

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Uric acid sodium Chemical Structure

Uric acid sodium Chemical Structure

CAS No. : 1198-77-2

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Other Forms of Uric acid sodium:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Uric acid sodium (400 μM;48 小时) 钠可保护 Caco-2 细胞免受吲哚美辛诱导的脂质过氧化[2]
用吲哚美辛和尿酸共同处理细胞 (200 μM IND加 400 μM UA;24 小时) 钠与仅用吲哚美辛孵育的细胞相比显著降低 ROS 水平。用吲哚美辛和 Uric acid sodium (200 μM IND 加 400 μM UA;24 小时) 钠处理的 Caco-2 细胞的细胞活力高于仅用吲哚美辛处理的细胞。尿酸钠通过其抗氧化活性对吲哚美辛引起的肠细胞变化具有保护作用[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

uric acid sodium (250 mg/kg;口服) 可改善吲哚美辛诱导的肠病[2]
口服 uric acid sodium 可减少吲哚美辛小鼠模型中回肠中 ROS 的积累-诱发性肠病[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57BL/6J mice[2]
Dosage: 250 mg/kg body weight
Administration: P.o.
Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
Clinical Trial
分子量

190.09

Formula

C5H3N4NaO3

CAS 号
性状

固体

颜色

White to off-white

中文名称

尿酸钠盐

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

1M NaOH 中的溶解度 : 8.33 mg/mL (43.82 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

DMSO 中的溶解度 : 3.12 mg/mL (16.41 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2607 mL 26.3033 mL 52.6067 mL
5 mM 1.0521 mL 5.2607 mL 10.5213 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.92%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 5.2607 mL 26.3033 mL 52.6067 mL 131.5167 mL
5 mM 1.0521 mL 5.2607 mL 10.5213 mL 26.3033 mL
10 mM 0.5261 mL 2.6303 mL 5.2607 mL 13.1517 mL
15 mM 0.3507 mL 1.7536 mL 3.5071 mL 8.7678 mL
1M NaOH 20 mM 0.2630 mL 1.3152 mL 2.6303 mL 6.5758 mL
25 mM 0.2104 mL 1.0521 mL 2.1043 mL 5.2607 mL
30 mM 0.1754 mL 0.8768 mL 1.7536 mL 4.3839 mL
40 mM 0.1315 mL 0.6576 mL 1.3152 mL 3.2879 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Uric acid sodium
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