2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. VEGFR-2-IN-30

VEGFR-2-IN-30 是一种 VEGFR-2 抑制剂 (IC50: 66 nM)。VEGFR-2-IN-30 还抑制 PDGFR、EGFR 和 FGFR1，IC50s 分别为 180、98、82 nM。VEGFR-2-IN-30 将癌细胞阻滞在 S 期并诱导早期和晚期细胞凋亡 (apoptosis)。

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VEGFR-2-IN-30 Chemical Structure

VEGFR-2-IN-30 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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VEGFR-2-IN-30 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis[1].

IC50 & Target[1]

VEGFR2

66 nM (IC50)

体外研究
(In Vitro)

VEGFR-2-IN-30 (化合物 8f) (10 μM) 抑制 35% 的 UO-31 细胞生长[1]。
VEGFR-2-IN-30 (10 μg/mL, 72 h) 抑制 HUVEC 细胞迁移[1].
VEGFR-2-IN-30 (5.29 μM, 24 h) 在阻滞 UO-31 细胞 在S 期[1]。
VEGFR-2-IN-30 (5.29 μM, 24 h) 诱导 UO-31 细胞凋亡[1]。
VEGFR-2-IN-30 (5.29 μM, 24 h) 在 UO-31 细胞中增加 Bax 水平并下调 Bcl-2 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VEGFR-2-IN-30 相关抗体:

Cell Migration Assay [1]

Cell Line: NHUVEC
Concentration: 10 μg/mL
Incubation Time: 72 h
Result: Inhibited cell migration by 58.52%.

Apoptosis Analysis[1]

Cell Line: UO-31 cell
Concentration: 5.29 μM
Incubation Time: 24 h
Result: Increased early apoptotic cells from 0.61% to 23.51% and late apoptotic cells from 0.13% to 9.28%.
Increased the level of active caspase-3.
分子量

607.10

Formula

C28H23ClN6O4S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VEGFR-2-IN-30 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2-IN-30VEGFRVascular endothelial growth factor receptorAnticancerUO-31HUVECBax/Bcl-2Inhibitorinhibitorinhibit

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产品名称：
VEGFR-2-IN-30
目录号：
HY-151969
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