2. Anti-infection Immunology/Inflammation
  3. CMV PD-1/PD-L1
  4. VIPhyb

VIPhyb 是一种血管活性肠肽 (VIP) 受体拮抗剂。VIPhyb 能够抑制癌细胞增殖。VIPhyb 能够抑制 VIP 信号传导，增强 T 细胞免疫力并下调 PD1。VIPhyb 能减少炎症细胞因子的表达。VIPhyb 能增强病毒清除能力。VIPhyb 可用于癌症、感染、炎症和免疫相关研究，如非小细胞肺癌 (NSCLC)、巨细胞病毒感染和结肠炎。

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Custom Peptide Synthesis

VIPhyb

VIPhyb Chemical Structure

CAS No. : 125093-93-8

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥1160
In-stock
10 mg ￥1850
In-stock
25 mg ￥3500
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

VIPhyb 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VIPhyb is a vasoactive intestinal polypeptide (VIP) receptor antagonist. VIPhyb can inhibit VIP signaling, increase T-cell immunity and downregulate PD1. VIPhyb can inhibit cancer cell proliferation. VIPhyb can reduce inflammatory cytokine expression. VIPhyb can enhance viral clearance. VIPhyb can be used for the researches of cancer, infection and inflammation and immunology, such as non-small cell lung cancer (NSCLC), cytomegalovirus infection and colitis[1][2][3][4].

体外研究
(In Vitro)

VIPhyb 对 NCI-H1299 细胞的 IC50 值为 500 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VIPhyb 相关抗体:
体内研究
(In Vivo)

VIPhyb (10 μg/mouse，皮下注射，从感染前一天开始，每日一次，持续 1 周) 可促进感染小鼠巨细胞病毒 (mCMV) 的 C57BL/6 和 BALB/c 小鼠的病毒清除，并提高存活率[2]。
VIPhyb (0.1-1 μM，腹腔注射，每日一次，持续 11 天) 可减轻葡聚糖硫酸钠 (DSS) (HY-116282C) 诱导的结肠炎小鼠模型的炎症[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine cytomegalovirus (mCMV) -infected C57BL/6 and BALB/c mice[2]
Dosage: 10 μg/mouse
Administration: Subcutaneously injection, daily for 1 week starting the day prior to infection
Result: Prolonged survival of mice.
Had less inflammation and tissue damage in the liver.
Decreased intranuclear viral inclusions, inflammatory leukocytes, necrosis, and CMV-infected giant cells.
Increased the numbers of effector/memory CD8+ T-cells and mature NK cells were.
Prevented the up-regulation of PD-L1.
Increased CD80, CD86, and MHC-II expression.
Increased numbers of IFN-γ- and TNF-α-expressing NK cells and T-cells.
Decreased the percentage of Treg cells and levels of serum VEGF.
Animal Model: Dextran sodium sulfate (DSS)-induced colitis mice models[3]
Dosage: 0.1 and 1 μM
Administration: Intraperitoneally injection, daily for 11 days
Result: Led to a significant reduction of weight loss percentage and bloody diarrhea.
Reduced colonic weight/length ratio.
Decreased expression of IL-1, TNF-α, and IL-6.
分子量

3467.06

Formula

C154H257N49O40S
CAS 号
性状

固体

颜色

White to off-white

Sequence

Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Sequence Shortening

KPRRPYTDNYTRLRKQMAVKKYLNSILN-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (28.84 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2884 mL 1.4421 mL 2.8843 mL
5 mM 0.0577 mL 0.2884 mL 0.5769 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.73%

COA (293 KB) RP-HPLC (245 KB) MS (68 KB)

产品使用指南 (1538 KB)
参考文献

VIPhyb 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2884 mL 1.4421 mL 2.8843 mL 7.2107 mL
5 mM 0.0577 mL 0.2884 mL 0.5769 mL 1.4421 mL
10 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7211 mL
15 mM 0.0192 mL 0.0961 mL 0.1923 mL 0.4807 mL
20 mM 0.0144 mL 0.0721 mL 0.1442 mL 0.3605 mL
25 mM 0.0115 mL 0.0577 mL 0.1154 mL 0.2884 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VIPhyb125093-93-8CMVPD-1/PD-L1CytomegalovirusPD-1/Programmed death-ligand 1VIPVirusNSCLCPD1ColitisNCI-H1299Inhibitorinhibitorinhibit

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目录号：
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