2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. Wnt/β-catenin-IN-1

Wnt/β-catenin-IN-1 (compounds 17) 是一种 Wnt/β-catenin 信号通路抑制剂。Wnt/β-catenin-IN-1 可诱导结肠癌细胞凋亡，具有广谱抗癌活性，可用于多种实体肿瘤研究。

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Wnt/β-catenin-IN-1 Chemical Structure

Wnt/β-catenin-IN-1 Chemical Structure

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Wnt/β-catenin-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors[1].

体外研究
(In Vitro)

Wnt/β-catenin-IN-1 (compounds 17) (10 μM，48 h) 具有广谱抗癌活性，对试验中的 52 个肿瘤细胞系平均生长抑制率为 81.9%[1]。
Wnt/β-catenin-IN-1 (compounds 17) (10 μM，48 h) 对于对正常人类细胞系 (CCD841, MRC5) 的细胞毒性作用较低，对癌细胞具有一定的选择性[1]。
Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM，24 h/48 h) 剂量依赖性地触发细胞周期阻滞，增加了 G2/M 细胞周期期 HCT116 结肠癌细胞的数量[1]。
Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM，24 h) 使 HCT 结直肠癌细胞中的 CDK8 水平呈剂量依赖性降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Wnt/β-catenin-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: HCT116, HCT15, HT29, KM12, SW620, KM12, COLO205, HCC2998, CCD841, MRC5, et al.
Concentration: 0.05 μM
Incubation Time: 48 h
Result: Showed broad-spectrum anticancer activity, less toxicity to normal cells, and certain selectivity to cancer cells.

Cell Cycle Analysis[1]

Cell Line: HCT116, HCT15, HT29, KM12, SW620, KM12, COLO205, HCC2998, CCD841, MRC5, et al.
Concentration: 0.05 μM
Incubation Time: 24 h
Result: Triggered G2/M cell cycle arrest by activating the p53-p21 pathway.
分子量

463.48

Formula

C26H25NO7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Wnt/β-catenin-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wnt/β-catenin-IN-1Wntβ-cateninBeta cateninWnt/β-Catenin signalingNatural productsStilbenoidsFlavanonesColon cancerCell cycleApoptosisp53-p21HCT116Inhibitorinhibitorinhibit

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