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WWL113 

目录号: HY-110148
产品使用指南

WWL113 是具有口服活性的、选择性的 Ces3Ces1f 的抑制剂,其对 Ces3Ces1fIC50 值分别为 120 nM 和 100 nM。WWL113 对 60-kDa丝氨酸水解酶(或水解酶)有极好的选择性。

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WWL113 Chemical Structure

WWL113 Chemical Structure

CAS No. : 947669-86-5

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Description

WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-kDa serine hydrolase (or hydrolases)[1].

IC50 & Target

IC50: 120 nM (Ces3), 100 nM (Ces1f)[1].

In Vitro

Ces3 and Ces1f are endoplasmic reticulum glycoproteins that have been previously associated with adipocyte lipolysis. WWL113 inhibits mouse recombinant Ces1, Ces1c, and ABHD6 at 10 μM[1].
WWL113 (1 μM) significantly increases UCP1 protein expression in brown adipocytes[2].
WWL113 has a partial, statistically significant inhibitory effect on blocking the buildup of PGE2[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WWL113 (30 mg/kg, orally once a day) results in major improvement of multiple features of metabolic syndrome and ameliorated obesity-diabetes in mice with lowered levels of nonesterified free fatty acids (NEFAs), triglycerides (TGs), total cholesterol and fasted glucose as well as enhanced glucose tolerance[1].
WWL113 ameliorates obesity-diabetes in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old db/db mice (n = 10 per group)[1].
Dosage: 30 mg/kg.
Administration: Orally once a day for 3 weeks.
Result: Corrected multiple features of metabolic syndrome in db/db mice.
Molecular Weight

466.53

Formula

C₂₉H₂₆N₂O₄

CAS No.

947669-86-5

SMILES

CN(CC1=CC(C2=CC=NC=C2)=CC=C1)C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

WWL113WWL 113WWL-113OthersUCP1ABHD6glucoseInhibitorinhibitorinhibit

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产品名称:
WWL113
目录号:
HY-110148
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