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  3. Zedoarondiol

Zedoarondiol  (Synonyms: 莪术奥酮二醇;蓬莪二醇)

目录号: HY-122915 纯度: 98.99%
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Zedoarondiol,一种倍半萜内酯化合物,具有抗氧化和抗炎活性。Zedoarondiol 可用于动脉粥样硬化研究。

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Zedoarondiol Chemical Structure

Zedoarondiol Chemical Structure

CAS No. : 98644-24-7

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  • 生物活性

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  • 参考文献

生物活性

Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research[1][2].

体外研究
(In Vitro)

Zedoarondiol (5-20 μg/mL) attenuates HUVECs injury, up-regulated SOD activity, suppressed formation of MDA and ROS, and secretion and protein expression of IL-1β, TNF-α, and MCP-1 in injured HUVECs induced by oxidized low-density lipoprotein (ox-LDL)[1].
Zedoarondiol induces nuclear Nrf2 translocation from cytoplasm into nucleus and up-regulated expression of HO-1, NQO1, and Nrf2 in nucleus[1].
Zedoarondiol suppresses PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation and DNA synthesis, and induces cell cycle arrest in G0/G1 phase. In addition, Zedoarondiol activates AMPK and ACC, inhibited the phosphorylation of mTOR and p70S6K, increases the expression of p53 and p21, and decreases the expression of CDK2 and cyclin E[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

252.35

Formula

C15H24O3

CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

莪术奥酮二醇;蓬莪二醇

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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