2. Inhibitory Antibodies
  3. Zolbetuximab

Zolbetuximab  (Synonyms: IMAB362)

目录号: HY-P99058 纯度: 96.98%
COA

摩尔计算器

Zolbetuximab (IMAB362) 是一种靶向 Claudin-18.2 的单克隆抗体。Zolbetuximab 通过免疫效应机制介导对 Claudin-18.2 阳性细胞的特异性杀伤。Zolbetuximab 可用于胃肠道腺癌和胰腺肿瘤的研究。

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Zolbetuximab Chemical Structure

Zolbetuximab Chemical Structure

CAS No. : 1496553-00-4

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规格 价格 是否有货 数量
1 mg ￥2800
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5 mg ￥7900
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Zolbetuximab 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors[1].

体外研究
(In Vitro)

Zolbetuximab (0-100 μg/mL) 与 CLDN18.2+ PC 细胞结合，诱导抗体依赖性细胞毒性 (ADCC) 和补体依赖性细胞毒性 (CDC)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zolbetuximab 相关抗体:
体内研究
(In Vivo)

单独使用 Zolbetuximab (200 μg，静脉注射) 以及与 Gemcitabine (HY-17026) (50 mg/kg，腹腔注射) 联合使用，在小鼠 BxPC-3-CLDN18.2 异种移植模型中表现出抗肿瘤活性[2]。
Zolbetuximab (5.7 mg/kg，腹腔注射，每周 3 次，持续五周) 抑制 SNU-620 细胞异种移植模型中的肿瘤生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mouse BxPC-3-CLDN18.2, MIA PaCa-2-CLDN18.2 xenograft model[2]
Dosage: 200 μg alone or with 50 mg/kg Gemcitabine
Administration: i.v.; i.p. (Gemcitabine)
Result: Inhibited tumor growth in two models, and prevented lung metastasis formation.
Prolonged survival time, and lowered fractions of CLDN18.2+ cells in MIA PaCa-2-CLDN18.2 xenograft.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 96.98%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

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Keywords:

Zolbetuximab1496553-00-4IMAB362IMAB 362IMAB-362OthersClaudin-18.2gastrointestinal adenocarcinomaspancreatic tumorsInhibitorinhibitorinhibit

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