2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. ZYJ-25e

ZYJ-25e 是一种有效的组蛋白去乙酰化酶抑制剂 (HDACi)，对 HDAC6 和 HDAC8 的 IC50 分别为 0.047 μM 和 0.139 μM。ZYJ-25e 是一种含四氢异喹啉的异羟肟酸类似物。ZYJ-25e 在 MDA-MB231 异种移植模型中表现出显著的抗肿瘤效力。

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ZYJ-25e Chemical Structure

ZYJ-25e Chemical Structure

CAS No. : 1287261-04-4

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ZYJ-25e 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) with IC50s of 0.047 μM and 0.139 μM for HDAC6 and HDAC8, respectively. ZYJ-25e is a tetrahydroisoquinoline-bearing hydroxamic acid analogue. ZYJ-25e shows marked antitumor potency in the MDA-MB231 xenograft model[1].

IC50 & Target[1]

HDAC6

0.047 μM (IC50)

HDAC8

0.139 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.94 μM
Compound: 25e
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 21476600]
HeLa IC50
0.047 μM
Compound: 25e
Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
Inhibition of HDAC6 in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
[PMID: 21476600]
HeLa IC50
0.058 μM
Compound: 25e
Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
Inhibition of HDAC in human HeLa cell nuclear extract after 30 mins by fluorescence microplate reader
[PMID: 21476600]
HeLa IC50
37.1 μM
Compound: 25e
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 21476600]
HL-60 IC50
47.6 μM
Compound: 25e
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 21476600]
K562 IC50
1.47 μM
Compound: 25e
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 21476600]
MDA-MB-231 IC50
0.79 μM
Compound: 25e
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay
[PMID: 21476600]
NB-4 IC50
1.5 μM
Compound: 25e
Cytotoxicity against human NB4 cells after 48 hrs by MTT assay
Cytotoxicity against human NB4 cells after 48 hrs by MTT assay
[PMID: 21476600]
分子量

584.66

Formula

C30H40N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ZYJ-25e 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZYJ-25e1287261-04-4HDACHistone deacetylasesTetrahydroisoquinolinehydroxamic acidMDA-MB231Inhibitorinhibitorinhibit

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产品名称：
ZYJ-25e
目录号：
HY-139795
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