1. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  2. DNA/RNA Synthesis ADC Cytotoxin
  3. β-Amanitin

β-Amanitin 是毒蘑菇中的一种环肽毒素。β-Amanitin 抑制真核RNA聚合酶 II 和 III (RNA polymerase II/III)。β-Amanitin 抑制蛋白质合成。β-Amanitin 可以用来作为抗体偶联活性分子 (ADCs) 的细胞毒性成分。

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β-Amanitin Chemical Structure

β-Amanitin Chemical Structure

CAS No. : 21150-22-1

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

β-Amanitin (0.01-100 µg/mL; 36 hours) shows toxicity in MCF-7 cells, and the rates of cell viability are calculated as 52%, 62%, 84%, 86%, and 91% at concentrations of 100, 10, 1, 0.1, and 0.01 µg/mL, respectively[2].
β-Amanitin shows a great inhibition of protein synthesis at both concentrations (10 µg/mL and 1 µg/mL) in MCF-7 cells for 24 hours[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: MCF-7 cells
Concentration: 0.01, 0.1, 1, 10, 100 µg/mL
Incubation Time: 36 hours
Result: Showed toxicity in MCF-7 cells.
分子量

919.95

Formula

C39H53N9O15S

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥96.0%

参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
β-Amanitin
目录号:
HY-125586
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