1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. DNA/RNA Synthesis
    ADC Cytotoxin
  3. ε-Amanitin

ε-Amanitin 

目录号: HY-131083
产品使用指南

ε-Amanitin,从多种蘑菇中分离出的环状肽,可有效与 RNA 聚合酶 II (RNA polymerase II) 结合并抑制其活性。

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ε-Amanitin Chemical Structure

ε-Amanitin Chemical Structure

CAS No. : 21705-02-2

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Description

ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

In Vitro

Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1].

Molecular Weight

903.96

Formula

C₃₉H₅₃N₉O₁₄S

CAS No.

21705-02-2

SMILES

O=[S](C[C@H](NC(CNC1=O)=O)C(N[C@H](C2=O)CC(O)=O)=O)C(N3)=C(C[C@@H](C(NCC(N[C@H]1[C@@H](C)CC)=O)=O)NC([C@@H](NC([C@H](C4)N2C[C@@H]4O)=O)[C@@H](C)[C@@H](O)C)=O)C(C3=C5)=CC=C5O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ε-AmanitinDNA/RNA SynthesisADC CytotoxinsynthesismRNAbiosynthesiscellularapoptosiscyclicpeptideInhibitorinhibitorinhibit

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产品名称:
ε-Amanitin
目录号:
HY-131083
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