1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. 3-Chlorodiphenylamine

3-Chlorodiphenylamine  (Synonyms: 3-氯二苯胺)

目录号: HY-131948
产品使用指南

3-Chlorodiphenylamine 是一种高亲和力的心肌 Ca2+ 增敏剂 (Ca2+ sensitizer)。3-Chlorodiphenylamine 基于二苯胺结构,可与心肌肌钙蛋白 C (cTnC) 的 N 端结构域可以结合 (Kd=6 µM)。3-Chlorodiphenylamine 由于分子体积小,可以作为开发更强 Ca2+ 增敏化合物的极好起始支架,用于收缩性心力衰竭的研究。

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3-Chlorodiphenylamine Chemical Structure

3-Chlorodiphenylamine Chemical Structure

CAS No. : 101-17-7

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生物活性

3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research[1].

IC50 & Target

Kd: 6 µM (N-domain of cardiac troponin C (cTnC))
Kd: 10 µM (cNTnC–cSp chimera)[1]

体外研究
(In Vitro)

3-Chlorodiphenylamine is able to bind highly (Kd=10 µM) to a chimeric protein consisting of the regulatory N-domain of cTnC (cNTnC) and the switch region of cTnI (cNTnC–cSp chimera)[1].
3-Chlorodiphenylamine (100 µM) results in a 1.5-fold increase in the Ca2+ sensitivity of force development without altering the maximal or resting forces in skinned ventricular trabeculae[1].
3-Chlorodiphenylamine (25-100 µM) increases Ca2+ sensitivity of the N-domain of intact cTnC after reconstitution into the cTn complex (cTnC complexed with cTnI and cTnT) in a concentration-dependent manner. It exhibits pCa50s with 6.39±0.01, 6.65±0.01, and 6.73±0.02 in the presence of 25, 50, and 100 µM 3-Chlorodiphenylamine, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

203.67

Formula

C12H10ClN

CAS 号
性状

液体

颜色

Light yellow to yellow

中文名称

3-氯二苯胺;间氯二苯胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

3-Chlorodiphenylamine 相关分类

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