2. MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR Epigenetics
  3. ERK Akt PI3K Epigenetic Reader Domain
  4. 6-O-Isobutyrylbritannilactone

6-O-Isobutyrylbritannilactone 

目录号: HY-N10802
产品使用指南

摩尔计算器

6-O-Isobutyrylbritannilactone 是一种天然的黑素生成抑制剂。6-O-Isobutyrylbritannilactone 是一种倍半萜，可从英菊花中分离得到。6-O-Isobutyrylbritannilactone 抑制 IBMX (HY-12318) 诱导 B16F10 细胞产生黑色素。6-O-Isobutyrylbritannilactone 也调控 ERK、PI3K/AKT 和 CREB，在斑马鱼胚胎模型中显示出抗黑色素原活性。

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6-O-Isobutyrylbritannilactone Chemical Structure

6-O-Isobutyrylbritannilactone Chemical Structure

CAS No. : 1259933-02-2

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6-O-Isobutyrylbritannilactone 相关抗体

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ERK ERK1 ERK2 ERK5 ERK8

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Akt Akt1 Akt2 Akt3

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models[1].

体外研究
(In Vitro)

6-O-Isobutyrylbritannilactone (5-100 μM; 48 h) 对 IBMX (100 μM; 24 h)[1]。
6-O-Isobutyrylbritannilactone (5-30 μM; 12 h) 剂量依赖性地抑制 IBMX 刺激 B16F10 细胞的白化相关 mRNA 水平 (100 μM; 48 h)[1]。
6-O-Isobutyrylbritannilactone (20 μM; 1-9 h) 时间依赖性地抑制 ERK、AKT 和 CREB 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

6-O-Isobutyrylbritannilactone 相关抗体:

RT-PCR[1]

Cell Line: B16F10 cells
Concentration: 5 μM, 10 μM, 20 μM, 30 μM
Incubation Time: 12 hours; with 100 μM IBMX for 48 hours
Result: Inhibited whitening-related mRNA levels, and resulted in completely inhibited expressions of melanogenesis-related protein levels at 20 μM.

Western Blot Analysis[1]

Cell Line: 20 μM
Concentration: 5 μM, 10 μM, 20 μM, 30 μM
Incubation Time: 1 h, 3 h, 6 h, and 9 h
Result: Inhibited the phosphorylation of ERK, AKT, and CREB. Demonstrated the melanogenesis suppression induced by IBMX via inaction of multiple signaling pathways.

Cell Cytotoxicity Assay[1]

Cell Line: B16F10 cells
Concentration: 5 μM, 10 μM, 20 μM, 50 μM, and 100 μM
Incubation Time: 24 hours
Result: Inhibited B16F10 cells viability in a dose-dependent manner.
体内研究
(In Vivo)

6-O-Isobutyrylbritannilactone (10-100 μM; 48 h) 与未处理的对照组相比，显著减少斑马鱼胚胎中的色素沉着[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish embryos[1]
Dosage: 10 μM, 50 μM, and 100 μM
Administration: Dipped in culture for 48 hours
Result: Reduced pigmentation by approximately 8%, 13%, and 16%.
分子量

336.42

Formula

C19H28O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6-O-Isobutyrylbritannilactone 相关分类

  • 摩尔计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-O-Isobutyrylbritannilactone1259933-02-2ERKAktPI3KEpigenetic Reader DomainExtracellular signal regulated kinasesPKBProtein kinase BPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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