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  3. BDP9066

BDP9066 

目录号: HY-111424
产品使用指南

BDP9066 是肌强直性肌营养不良相关 Cdc-42 结合激酶 MRCK 的选择性有效抑制剂,其在 SCC12 细胞中测得对 MRCKβ 的IC50 值为 64 nM,对 MRCKα/β 的 Ki 值分别为 0.0136 nM 和 0.0233 nM。BDP9066 可用来研究皮肤癌。

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BDP9066 Chemical Structure

BDP9066 Chemical Structure

CAS No. : 2226507-04-4

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Description

BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.

IC50 & Target

IC50: 64 nM (MRCKβ in SCC12 cells), Ki: 0.0136 nM/0.0233 nM (MRCKα/β)[1].

In Vitro

BDP9066 shows antiproliferative effects with greatest activity in hematologic cancer cells. BDP9066 inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion[1].

In Vivo

BDP9066 topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes[1].

Molecular Weight

348.44

Formula

C₂₀H₂₄N₆

CAS No.

2226507-04-4

SMILES

C12=C(N3CCC[C@@]4(CCCCN4)C3)C=CNC1=NC=C2C5=NC=NC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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  • 稀释计算器

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× = ×
C1   V1   C2   V2

Keywords:

BDP9066BDP 9066BDP-9066RasInhibitorinhibitorinhibit

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产品名称:
BDP9066
目录号:
HY-111424
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